Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]

Ramon Martinez, Gabriele Schackert, Ricard Yaya-Tur, Iñigo Rojas-Marcos, James G. Herman, Manel Esteller

Research output: Contribution to journalArticle

Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

Original languageEnglish (US)
Pages (from-to)91-93
Number of pages3
JournalJournal of Neuro-Oncology
Volume83
Issue number1
DOIs
StatePublished - May 2007

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Glioblastoma
DNA Repair
Survivors
Methylation
Genes
Survival
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

Cite this

Martinez, R., Schackert, G., Yaya-Tur, R., Rojas-Marcos, I., Herman, J. G., & Esteller, M. (2007). Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]. Journal of Neuro-Oncology, 83(1), 91-93. https://doi.org/10.1007/s11060-006-9292-0

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]. / Martinez, Ramon; Schackert, Gabriele; Yaya-Tur, Ricard; Rojas-Marcos, Iñigo; Herman, James G.; Esteller, Manel.

In: Journal of Neuro-Oncology, Vol. 83, No. 1, 05.2007, p. 91-93.

Research output: Contribution to journalArticle

Martinez, R, Schackert, G, Yaya-Tur, R, Rojas-Marcos, I, Herman, JG & Esteller, M 2007, 'Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]', Journal of Neuro-Oncology, vol. 83, no. 1, pp. 91-93. https://doi.org/10.1007/s11060-006-9292-0
Martinez, Ramon ; Schackert, Gabriele ; Yaya-Tur, Ricard ; Rojas-Marcos, Iñigo ; Herman, James G. ; Esteller, Manel. / Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]. In: Journal of Neuro-Oncology. 2007 ; Vol. 83, No. 1. pp. 91-93.
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