Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]

Ramon Martinez; Gabriele Schackert; Ricard Yaya-Tur; Iñigo Rojas-Marcos; James G. Herman; Manel Esteller

doi:10.1007/s11060-006-9292-0

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]

Ramon Martinez, Gabriele Schackert, Ricard Yaya-Tur, Iñigo Rojas-Marcos, James G. Herman, Manel Esteller

School of Medicine

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

Original language	English (US)
Pages (from-to)	91-93
Number of pages	3
Journal	Journal of Neuro-Oncology
Volume	83
Issue number	1
DOIs	https://doi.org/10.1007/s11060-006-9292-0
State	Published - May 2007

ASJC Scopus subject areas

Clinical Neurology
Cancer Research
Oncology
General Neuroscience

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AU - Rojas-Marcos, Iñigo

AU - Herman, James G.

AU - Esteller, Manel

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AB - We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

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Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]

Abstract

ASJC Scopus subject areas

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