Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme [1]

Ramon Martinez, Gabriele Schackert, Ricard Yaya-Tur, Iñigo Rojas-Marcos, James G. Herman, Manel Esteller

Research output: Contribution to journalArticlepeer-review

Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

Original languageEnglish (US)
Pages (from-to)91-93
Number of pages3
JournalJournal of Neuro-Oncology
Volume83
Issue number1
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

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