Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

Jianming Ying; Zifen Gao; Hongyu Li; Gopesh Srivastava; Paul G. Murray; Hwee Koon Goh; Chai Yen Lim; Yajun Wang; Teresa Marafioti; David Y. Mason; Richard F. Ambinder; Anthony T.C. Chan; Qian Tao

doi:10.1111/j.1365-2141.2007.06512.x

Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

Jianming Ying, Zifen Gao, Hongyu Li, Gopesh Srivastava, Paul G. Murray, Hwee Koon Goh, Chai Yen Lim, Yajun Wang, Teresa Marafioti, David Y. Mason, Richard F. Ambinder, Anthony T.C. Chan, Qian Tao

School of Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

Original language	English (US)
Pages (from-to)	829-832
Number of pages	4
Journal	British journal of haematology
Volume	136
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06512.x
State	Published - Mar 2007

Keywords

Biomarker
Lymphoma
Methylation
PCDH10
Tumour suppressor gene

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2007.06512.x

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Ying, J., Gao, Z., Li, H., Srivastava, G., Murray, P. G., Goh, H. K., Lim, C. Y., Wang, Y., Marafioti, T., Mason, D. Y., Ambinder, R. F., Chan, A. T. C., & Tao, Q. (2007). Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies. British journal of haematology, 136(6), 829-832. https://doi.org/10.1111/j.1365-2141.2007.06512.x

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abstract = "Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.",

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author = "Jianming Ying and Zifen Gao and Hongyu Li and Gopesh Srivastava and Murray, {Paul G.} and Goh, {Hwee Koon} and Lim, {Chai Yen} and Yajun Wang and Teresa Marafioti and Mason, {David Y.} and Ambinder, {Richard F.} and Chan, {Anthony T.C.} and Qian Tao",

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doi = "10.1111/j.1365-2141.2007.06512.x",

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AU - Ying, Jianming

AU - Gao, Zifen

AU - Li, Hongyu

AU - Srivastava, Gopesh

AU - Murray, Paul G.

AU - Goh, Hwee Koon

AU - Lim, Chai Yen

AU - Wang, Yajun

AU - Marafioti, Teresa

AU - Mason, David Y.

AU - Ambinder, Richard F.

AU - Chan, Anthony T.C.

AU - Tao, Qian

PY - 2007/3

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N2 - Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

AB - Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

KW - Biomarker

KW - Lymphoma

KW - Methylation

KW - PCDH10

KW - Tumour suppressor gene

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Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

Abstract

Keywords

ASJC Scopus subject areas

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