Frequent BRAF mutation in early-onset colorectal cancer in Taiwan: Association with distinct clinicopathological and molecular features and poor clinical outcome

Jia Huei Tsai, Jau Yu Liau, Yu Lin Lin, Li Hui Tseng, Liang In Lin, Kun Huei Yeh, Yung Ming Jeng

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Occurrence of early-onset colorectal cancer (EOCRC) under the age of 30 is very rare and the molecular characteristics are poorly understood. A low BRAF mutation rate has been noted in several studies of EOCRC from Western countries. Aims: To determine the clinicopathological and molecular features of EOCRCs in Taiwan. Methods: KRAS/BRAF gene mutation, mismatch repair protein immunohistochemistry, microsatellite instability and CpG island methylation phenotype analyses were examined to determine the molecular characteristics of EOCRC. Results: Sixty-six patients with EOCRC at our hospital between 2000 and 2012 were studied. BRAF mutation was detected in 11 of the 59 tumours analysed (19%) and the rate was significantly higher than the overall BRAF mutation rate of colorectal cancer in patients older than 30 years (p

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalJournal of Clinical Pathology
Volume69
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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