Frequent β-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential

Julie M. Wu, Elizabeth A. Montgomery, Christine A. Iacobuzio-Donahue

Research output: Contribution to journalArticle

Abstract

We obtained 22 sessile serrated adenomas (SSAs) and 19 hyperplastic polyps (HPs) and performed immunolabeling for cytokeratins (CKs) 7 and 20, CDX2, β-catenin, and p53 to determine the role of these markers in aiding distinction of lesions with neoplastic potential. Patients with SSAs more frequently had a prior or coexistent tubular adenoma (P = .004) that was right-sided (P = .00001) and larger (P = .03). No difference in CK7, CK20, or p53 labeling was found after correction for colonic location. However, CDX2 labeling was significantly lower in SSAs (P = .02) and was predominantly confined to the crypt bases, whereas it was diffusely positive in HPs (P < .001). Surprisingly, aberrant nuclear labeling for β-catenin was found in 9 (41%) of the SSAs but in none of the HPs (P < .002). We propose that β-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development.

Original languageEnglish (US)
Pages (from-to)416-423
Number of pages8
JournalAmerican journal of clinical pathology
Volume129
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Colorectal
  • Hyperplastic polyps
  • Serrated adenoma
  • Wnt pathway

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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