TY - JOUR
T1 - Frequent β-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential
AU - Wu, Julie M.
AU - Montgomery, Elizabeth A.
AU - Iacobuzio-Donahue, Christine A.
PY - 2008/3
Y1 - 2008/3
N2 - We obtained 22 sessile serrated adenomas (SSAs) and 19 hyperplastic polyps (HPs) and performed immunolabeling for cytokeratins (CKs) 7 and 20, CDX2, β-catenin, and p53 to determine the role of these markers in aiding distinction of lesions with neoplastic potential. Patients with SSAs more frequently had a prior or coexistent tubular adenoma (P = .004) that was right-sided (P = .00001) and larger (P = .03). No difference in CK7, CK20, or p53 labeling was found after correction for colonic location. However, CDX2 labeling was significantly lower in SSAs (P = .02) and was predominantly confined to the crypt bases, whereas it was diffusely positive in HPs (P < .001). Surprisingly, aberrant nuclear labeling for β-catenin was found in 9 (41%) of the SSAs but in none of the HPs (P < .002). We propose that β-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development.
AB - We obtained 22 sessile serrated adenomas (SSAs) and 19 hyperplastic polyps (HPs) and performed immunolabeling for cytokeratins (CKs) 7 and 20, CDX2, β-catenin, and p53 to determine the role of these markers in aiding distinction of lesions with neoplastic potential. Patients with SSAs more frequently had a prior or coexistent tubular adenoma (P = .004) that was right-sided (P = .00001) and larger (P = .03). No difference in CK7, CK20, or p53 labeling was found after correction for colonic location. However, CDX2 labeling was significantly lower in SSAs (P = .02) and was predominantly confined to the crypt bases, whereas it was diffusely positive in HPs (P < .001). Surprisingly, aberrant nuclear labeling for β-catenin was found in 9 (41%) of the SSAs but in none of the HPs (P < .002). We propose that β-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development.
KW - Colorectal
KW - Hyperplastic polyps
KW - Serrated adenoma
KW - Wnt pathway
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UR - http://www.scopus.com/inward/citedby.url?scp=41649102270&partnerID=8YFLogxK
U2 - 10.1309/603UQKM7C2KELGJU
DO - 10.1309/603UQKM7C2KELGJU
M3 - Article
C2 - 18285264
AN - SCOPUS:41649102270
SN - 0002-9173
VL - 129
SP - 416
EP - 423
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 3
ER -