Frequency of sustained intracranial pressure elevation during treatment of severe intraventricular hemorrhage

Wendy C Ziai, Michel T. Torbey, Neal J. Naff, Michael A. Williams, Ross Bullock, Anthony Marmarou, Stanley Tuhrim, Eric Schmutzhard, Bettina Pfausler, Daniel F Hanley

Research output: Contribution to journalArticle

Abstract

Background: Elevated intracranial pressure (ICP) is an important marker of neurological deterioration. The occurrence and significance of elevated ICP and low cerebral perfusion pressure (CPP) in aggressively treated spontaneous intraventricular hemorrhage (IVH) are not defined. Methods: We performed a secondary longitudinal exploratory data analysis of a randomized multicenter trial of urokinase (UK) versus placebo (Pcb) as a treatment for IVH. Eleven IVH patients who required an external ventricular drain (EVD) were randomized to receive either intraventricular UK or Pcb every 12 h until clinical response permitted EVD removal. ICP and CPP were recorded every 4 or 6 h, as well as before and 1 h after EVD closure for administration of study agent. ICP, CPP and the proportion of ICP readings above 20, 30, 40 and 50 mm Hg were analyzed. Results: Six UK and 5 Pcb patients aged 39-74 years (mean ± standard deviation; 53 ± 11 years) were enrolled. Initial ICP ranged from 0 to 38 mm Hg (10.9 ± 11.0), initial CPP from 65 to 133 mm Hg (100.5 ± 17.7). We recorded 472 ICP readings over the entire monitoring period. Of these 65 (14%) were >20 mm Hg, 23 (5%) >30 mm Hg, 9 (2%) >40 mm Hg and 3 (50 mm Hg. Only 2 of 141 intraventricular injections of study agent with EVD closure were not tolerated and required reopening of the EVD. Conclusions: In the intensive care unit, initial ICP measured with an EVD was uncommonly elevated (1/11 patients) in this group of severe IVH patients despite acute obstructive hydrocephalus. Frequent monitoring reveals ICP elevation >20 mm Hg in 14% of observations during use of EVD. ICP elevation, though it can occur, is not routinely associated with EVD closure for thrombolytic treatment with UK.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalCerebrovascular Diseases
Volume27
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Intracranial Hypertension
Cerebrovascular Circulation
Intracranial Pressure
Urokinase-Type Plasminogen Activator
Hemorrhage
Placebos
Reading
Therapeutics
Intraventricular Injections
Hydrocephalus
Multicenter Studies
Intensive Care Units

Keywords

  • Hydrocephalus
  • Intracerebral hemorrhage
  • Intracranial pressure
  • Stroke
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Frequency of sustained intracranial pressure elevation during treatment of severe intraventricular hemorrhage. / Ziai, Wendy C; Torbey, Michel T.; Naff, Neal J.; Williams, Michael A.; Bullock, Ross; Marmarou, Anthony; Tuhrim, Stanley; Schmutzhard, Eric; Pfausler, Bettina; Hanley, Daniel F.

In: Cerebrovascular Diseases, Vol. 27, No. 4, 04.2009, p. 403-410.

Research output: Contribution to journalArticle

Ziai, WC, Torbey, MT, Naff, NJ, Williams, MA, Bullock, R, Marmarou, A, Tuhrim, S, Schmutzhard, E, Pfausler, B & Hanley, DF 2009, 'Frequency of sustained intracranial pressure elevation during treatment of severe intraventricular hemorrhage', Cerebrovascular Diseases, vol. 27, no. 4, pp. 403-410. https://doi.org/10.1159/000209241
Ziai, Wendy C ; Torbey, Michel T. ; Naff, Neal J. ; Williams, Michael A. ; Bullock, Ross ; Marmarou, Anthony ; Tuhrim, Stanley ; Schmutzhard, Eric ; Pfausler, Bettina ; Hanley, Daniel F. / Frequency of sustained intracranial pressure elevation during treatment of severe intraventricular hemorrhage. In: Cerebrovascular Diseases. 2009 ; Vol. 27, No. 4. pp. 403-410.
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AU - Torbey, Michel T.

AU - Naff, Neal J.

AU - Williams, Michael A.

AU - Bullock, Ross

AU - Marmarou, Anthony

AU - Tuhrim, Stanley

AU - Schmutzhard, Eric

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AU - Hanley, Daniel F

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KW - Intracerebral hemorrhage

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KW - Stroke

KW - Thrombolysis

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