Frequency of long-term nonprogressors in HIV-1 seroconverters from rakai uganda

Oliver B. Laeyendecker, Andrew Redd, Tom Lutalo, Ronald H Gray, Maria J Wawer, Victor Ssempijja, Jordyn Gamiel, John Baptist Bwanika, Fred Makumbi, Fred Nalugoda, Pius Opendi, Godfrey Kigozi, Anthony Ndyanabo, Boaz Iga, Noah Kiwanuka, Nelson Sewankambo, Steven James Reynolds, David Serwadda, Thomas C Quinn

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Studies on long-term nonprogressors (LTNP) have been conducted in the USA and Europe. This study examined the frequency of LTNPs and HIV controllers among 637 HIV-1 seroconverters in rural Uganda. DESIGN AND METHODS:: LTNPs were defined as being infected for more than 7 years with a CD4 T-cell count above 600 cells per microliter, and HIV controllers as having undetectable viral loads on 3 separate occasions without antiretroviral treatment. HIV-1 viral load and subtype distribution between LTNP and non-LTNP populations were determined. RESULTS:: Of the HIV seroconverters, 9.1% (58/637) were LTNPs and 1.4% (9/637) were HIV controllers. LTNPs had a significantly lower viral load at set point than non-LTNP participants (P <0.001). The Kaplan-Meier joint probability of surviving to 7 years with a CD4 count >600 was 19.2%. Individuals who survived 7 years had a significantly higher frequency of HIV-1 subtype A (P <0.05), but seroconverters infected with HIV-1A did not have a significantly higher probability of becoming an LTNP. CONCLUSIONS:: The frequency of LTNPs appears to be relatively high in Uganda and it may be important to take this into account when designing studies of viral pathogenesis and performing HIV vaccine trials in sub-Saharan Africa.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume52
Issue number3
DOIs
Publication statusPublished - Nov 2009

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Keywords

  • Africa
  • HIV
  • HIV disease progression
  • Long-term nonprogressors

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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