Frequency of Adverse Systemic Reactions after Fluorescein Angiography: Results of a Prospective Study

Kris A. Kwiterovich, Maureen G. Maguire, Robert P. Murphy, Andrew P. Schachat, Neil M. Bressler, Susan B. Bressler, Stuart L. Fine

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous fluorescein angiography is a commonly performed and extraordinarily valuable diagnostic procedure. The frequency of adverse reactions after angiography has varied considerably in previous reports. In a prospective study of 2789 angiographic procedures in 2025 patients, the authors found that the percentage of adverse reactions depended strongly on the patient's angiographic history. Overall, adverse reactions followed 4.8% of the angiographic procedures. These reactions included nausea (2.9%), vomiting (1.2%), flushing/itching/hives (0.5%), and other reactions (dyspnea, syncope, excessive sneezing) (0.2%). No cases of anaphylaxis, myocardial infarction, pulmonary edema, or seizures occurred. The percentage of reactions was 1.8% for patients who had had previous angiography without ever having had an adverse reaction. In contrast, the percentage of reactions was 48.6% for patients who had had an adverse reaction to angiography previously.

Original languageEnglish (US)
Pages (from-to)1139-1142
Number of pages4
JournalOphthalmology
Volume98
Issue number7
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Ophthalmology

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