Freedom from atrial tachyarrhythmias after catheter ablation of atrial fibrillation: A randomized comparison between 2 current ablation strategies

Martin R. Karch, Bernhard Zrenner, Isabel Deisenhofer, Jürgen Schreieck, Gjin Ndrepepa, Jun Dong, Katrin Lamprecht, Petra Barthel, Etienne Luciani, Albert Schömig, Claus Schmitt

Research output: Contribution to journalArticle

Abstract

Background - Data on the comparative value of the circumferential pulmonary vein and the segmental pulmonary vein ablation for interventional treatment of atrial fibrillation are limited. We hypothesized that the circumferential pulmonary vein ablation approach was superior to the segmental pulmonary vein ablation approach. Methods and Results - One hundred patients with highly symptomatic atrial fibrillation were randomly assigned to undergo either circumferential (n=50) or segmental pulmonary vein ablation (n=50). Freedom from atrial tachyarrhythmias in a 7-day Holler monitoring at 6 months was the primary end point. Secondary end points were freedom of arrhythmia-related symptoms and a composite of pericardial tamponade, thromboembolic complications, and pulmonary vein stenosis (safety end point). On the basis of the results of the 7-day Holler monitoring at 6 months, 21 patients (42%) after circumferential pulmonary vein ablation and 33 patients (66%) after segmental pulmonary vein ablation (P=0.02) were free of atrial tachyarrhythmia episodes. During the 6-month follow-up period, 27 patients (54%) after circumferential pulmonary vein ablation and 41 patients (82%) after segmental pulmonary vein ablation remained free of arrhythmia-related symptoms (P

Original languageEnglish (US)
Pages (from-to)2875-2880
Number of pages6
JournalCirculation
Volume111
Issue number22
DOIs
StatePublished - Jun 7 2005
Externally publishedYes

Keywords

  • Ablation
  • Atrial fibrillation
  • Atrium
  • Electrophysiology
  • Fibrillation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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