Free thyroxine and functional mobility, fitness, and fatigue in euthyroid older men and women in the Baltimore Longitudinal Study of Aging

Eleanor Marie Simonsick, Chee W. Chia, Jennifer S Mammen, Josephine M. Egan, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background: Emerging evidence suggests that mildly down-regulated thyroid function in older persons may protect and/or reflect maintained health. Methods: Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0.76-1.50 ng/dL) as a continuous variable and categorized as low (lower quartile), medium (interquartile), or high (upper quartile). Results: Adjusting for sex, age, race, height, weight, exercise and smoking, reported walking ability, usual and rapid gait speed, 400-m time, fatigability, and reported energy level were less favorable with increasing FT4 (p=.013 to

Original languageEnglish (US)
Pages (from-to)961-967
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume71
Issue number7
DOIs
StatePublished - 2016

Fingerprint

Baltimore
Aptitude
Thyroxine
Walking
Fatigue
Longitudinal Studies
Thyroid Gland
Volunteers
Reference Values
Cohort Studies
Smoking
Exercise
Weights and Measures
Health
Walking Speed

Keywords

  • Aging
  • Fatigue
  • Fitness
  • Free thyroxine
  • Physical function

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

@article{2acbaae51999480a95137b0b6314afaa,
title = "Free thyroxine and functional mobility, fitness, and fatigue in euthyroid older men and women in the Baltimore Longitudinal Study of Aging",
abstract = "Background: Emerging evidence suggests that mildly down-regulated thyroid function in older persons may protect and/or reflect maintained health. Methods: Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0.76-1.50 ng/dL) as a continuous variable and categorized as low (lower quartile), medium (interquartile), or high (upper quartile). Results: Adjusting for sex, age, race, height, weight, exercise and smoking, reported walking ability, usual and rapid gait speed, 400-m time, fatigability, and reported energy level were less favorable with increasing FT4 (p=.013 to",
keywords = "Aging, Fatigue, Fitness, Free thyroxine, Physical function",
author = "Simonsick, {Eleanor Marie} and Chia, {Chee W.} and Mammen, {Jennifer S} and Egan, {Josephine M.} and Luigi Ferrucci",
year = "2016",
doi = "10.1093/gerona/glv226",
language = "English (US)",
volume = "71",
pages = "961--967",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Free thyroxine and functional mobility, fitness, and fatigue in euthyroid older men and women in the Baltimore Longitudinal Study of Aging

AU - Simonsick, Eleanor Marie

AU - Chia, Chee W.

AU - Mammen, Jennifer S

AU - Egan, Josephine M.

AU - Ferrucci, Luigi

PY - 2016

Y1 - 2016

N2 - Background: Emerging evidence suggests that mildly down-regulated thyroid function in older persons may protect and/or reflect maintained health. Methods: Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0.76-1.50 ng/dL) as a continuous variable and categorized as low (lower quartile), medium (interquartile), or high (upper quartile). Results: Adjusting for sex, age, race, height, weight, exercise and smoking, reported walking ability, usual and rapid gait speed, 400-m time, fatigability, and reported energy level were less favorable with increasing FT4 (p=.013 to

AB - Background: Emerging evidence suggests that mildly down-regulated thyroid function in older persons may protect and/or reflect maintained health. Methods: Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0.76-1.50 ng/dL) as a continuous variable and categorized as low (lower quartile), medium (interquartile), or high (upper quartile). Results: Adjusting for sex, age, race, height, weight, exercise and smoking, reported walking ability, usual and rapid gait speed, 400-m time, fatigability, and reported energy level were less favorable with increasing FT4 (p=.013 to

KW - Aging

KW - Fatigue

KW - Fitness

KW - Free thyroxine

KW - Physical function

UR - http://www.scopus.com/inward/record.url?scp=84979236355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979236355&partnerID=8YFLogxK

U2 - 10.1093/gerona/glv226

DO - 10.1093/gerona/glv226

M3 - Article

C2 - 26791089

AN - SCOPUS:84979236355

VL - 71

SP - 961

EP - 967

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 7

ER -