Free running erbium

YAG laser for nonmechanical trephination in penetrating keratoplasty: First results of experimental trephination of human donor corneas

Michael Küchle, Ashley Behrens, Berthold Seitz, Achim Langenbucher, Gottfried O H Naumann

Research output: Contribution to journalArticle

Abstract

Background: A study was carried out to evaluate the potential suitability of a free-running erbium:YAG 2.94-μm laser for trephina tion of human corneas in penetrating keratoplasty. Methods: Two human donor corneas were placed in an artificial anterior chamber and moved with an automated rotation device (one rotation per minute). An erbium:YAG laser beam (pulse duration 400 μs, repetition rate 2/s, energy density 2.5 and 15.0 J/cm2) was focused on the outer edge of a round ceramic mask placed on the human donor corneas for ablation of tissue. Results: With a fluence of 15.0 J/cm2, perforation was achieved after 500 pulses. Perpendicular central cut edges with mild stromal ridges and, by light microscopy, a 12 to 45-μm area of stromal thermal effects and focal endothelial changes up to 200 μm central to trephination were observed. Conclusions: The erbium:YAG laser could be a promising 'low-cost alternative' to the excimer laser for nonmechanical trephination in penetrating keratoplasty. Further studies will have to focus on reduction of thermal damage and on wound healing.

Original languageEnglish (US)
Pages (from-to)875-877
Number of pages3
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume237
Issue number10
DOIs
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Trephining
Penetrating Keratoplasty
Solid-State Lasers
Running
Cornea
Hot Temperature
Erbium
Excimer Lasers
Ceramics
Anterior Chamber
Masks
Wound Healing
Microscopy
Lasers
Light
Costs and Cost Analysis
Equipment and Supplies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Free running erbium : YAG laser for nonmechanical trephination in penetrating keratoplasty: First results of experimental trephination of human donor corneas. / Küchle, Michael; Behrens, Ashley; Seitz, Berthold; Langenbucher, Achim; Naumann, Gottfried O H.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 237, No. 10, 10.1999, p. 875-877.

Research output: Contribution to journalArticle

@article{e0570df7dfab43639570efb2b678775c,
title = "Free running erbium: YAG laser for nonmechanical trephination in penetrating keratoplasty: First results of experimental trephination of human donor corneas",
abstract = "Background: A study was carried out to evaluate the potential suitability of a free-running erbium:YAG 2.94-μm laser for trephina tion of human corneas in penetrating keratoplasty. Methods: Two human donor corneas were placed in an artificial anterior chamber and moved with an automated rotation device (one rotation per minute). An erbium:YAG laser beam (pulse duration 400 μs, repetition rate 2/s, energy density 2.5 and 15.0 J/cm2) was focused on the outer edge of a round ceramic mask placed on the human donor corneas for ablation of tissue. Results: With a fluence of 15.0 J/cm2, perforation was achieved after 500 pulses. Perpendicular central cut edges with mild stromal ridges and, by light microscopy, a 12 to 45-μm area of stromal thermal effects and focal endothelial changes up to 200 μm central to trephination were observed. Conclusions: The erbium:YAG laser could be a promising 'low-cost alternative' to the excimer laser for nonmechanical trephination in penetrating keratoplasty. Further studies will have to focus on reduction of thermal damage and on wound healing.",
author = "Michael K{\"u}chle and Ashley Behrens and Berthold Seitz and Achim Langenbucher and Naumann, {Gottfried O H}",
year = "1999",
month = "10",
doi = "10.1007/s004170050326",
language = "English (US)",
volume = "237",
pages = "875--877",
journal = "Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie",
issn = "0721-832X",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - Free running erbium

T2 - YAG laser for nonmechanical trephination in penetrating keratoplasty: First results of experimental trephination of human donor corneas

AU - Küchle, Michael

AU - Behrens, Ashley

AU - Seitz, Berthold

AU - Langenbucher, Achim

AU - Naumann, Gottfried O H

PY - 1999/10

Y1 - 1999/10

N2 - Background: A study was carried out to evaluate the potential suitability of a free-running erbium:YAG 2.94-μm laser for trephina tion of human corneas in penetrating keratoplasty. Methods: Two human donor corneas were placed in an artificial anterior chamber and moved with an automated rotation device (one rotation per minute). An erbium:YAG laser beam (pulse duration 400 μs, repetition rate 2/s, energy density 2.5 and 15.0 J/cm2) was focused on the outer edge of a round ceramic mask placed on the human donor corneas for ablation of tissue. Results: With a fluence of 15.0 J/cm2, perforation was achieved after 500 pulses. Perpendicular central cut edges with mild stromal ridges and, by light microscopy, a 12 to 45-μm area of stromal thermal effects and focal endothelial changes up to 200 μm central to trephination were observed. Conclusions: The erbium:YAG laser could be a promising 'low-cost alternative' to the excimer laser for nonmechanical trephination in penetrating keratoplasty. Further studies will have to focus on reduction of thermal damage and on wound healing.

AB - Background: A study was carried out to evaluate the potential suitability of a free-running erbium:YAG 2.94-μm laser for trephina tion of human corneas in penetrating keratoplasty. Methods: Two human donor corneas were placed in an artificial anterior chamber and moved with an automated rotation device (one rotation per minute). An erbium:YAG laser beam (pulse duration 400 μs, repetition rate 2/s, energy density 2.5 and 15.0 J/cm2) was focused on the outer edge of a round ceramic mask placed on the human donor corneas for ablation of tissue. Results: With a fluence of 15.0 J/cm2, perforation was achieved after 500 pulses. Perpendicular central cut edges with mild stromal ridges and, by light microscopy, a 12 to 45-μm area of stromal thermal effects and focal endothelial changes up to 200 μm central to trephination were observed. Conclusions: The erbium:YAG laser could be a promising 'low-cost alternative' to the excimer laser for nonmechanical trephination in penetrating keratoplasty. Further studies will have to focus on reduction of thermal damage and on wound healing.

UR - http://www.scopus.com/inward/record.url?scp=0345466323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345466323&partnerID=8YFLogxK

U2 - 10.1007/s004170050326

DO - 10.1007/s004170050326

M3 - Article

VL - 237

SP - 875

EP - 877

JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie

JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie

SN - 0721-832X

IS - 10

ER -