Free radicals and senescence

Teng Lu, Toren Finkel

Research output: Contribution to journalArticlepeer-review

232 Scopus citations


There is a significant body of experimental evidence that a rise in intracellular reactive oxygen species (ROS) contributes to senescence. Here we review experiments where entry into senescence has been evaluated in cells whose intracellular ROS levels have been modulated by growth in either high or low ambient oxygen concentrations, or where the cellular antioxidant status has been perturbed. In addition, we discuss the observations that senescence triggered by oncogene expression also appears to be in part mediated by a rise in ROS levels. Finally, we discuss the emerging evidence that in vivo senescence might also be triggered by a rise in cellular oxidant levels. Although these data tend to support a role for ROS in mediating senescence, significant questions remain as to whether ROS act in a random or specific fashion and what precise oxidant species acts as the potential senescence trigger.

Original languageEnglish (US)
Pages (from-to)1918-1922
Number of pages5
JournalExperimental Cell Research
Issue number9
StatePublished - Jun 10 2008
Externally publishedYes


  • Antioxidant
  • Hydrogen peroxide
  • Reactive oxygen species
  • Senescence
  • Telomere

ASJC Scopus subject areas

  • Cell Biology


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