Free-breathing 3D whole-heart black-blood imaging with motion sensitized driven equilibrium

Subashini Srinivasan, Peng Hu, Kraig V. Kissinger, Beth Goddu, Lois Goepfert, Ehud J. Schmidt, Sebastian Kozerke, Reza Nezafat

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the efficacy and robustness of motion sensitized driven equilibrium (MSDE) for blood suppression in volumetric 3D whole-heart cardiac MR. Materials and Methods: To investigate the efficacy of MSDE on blood suppression and myocardial signal-to-noise ratio (SNR) loss on different imaging sequences, seven healthy adult subjects were imaged using 3D electrocardiogram (ECG)-triggered MSDE-prep T1-weighted turbo spin echo (TSE), and spoiled gradient echo (GRE), after optimization of MSDE parameters in a pilot study of five subjects. Imaging artifacts, myocardial and blood SNR were assessed. Subsequently, the feasibility of isotropic spatial resolution MSDE-prep black-blood was assessed in six subjects. Finally, 15 patients with known or suspected cardiovascular disease were recruited to be imaged using a conventional multislice 2D double inversion recovery (DIR) TSE imaging sequence and a 3D MSDE-prep spoiled GRE. Results: The MSDE-prep yielded significant blood suppression (75%-92%), enabling a volumetric 3D black-blood assessment of the whole heart with significantly improved visualization of the chamber walls. The MSDE-prep also allowed successful acquisition of black-blood images with isotropic spatial resolution. In the patient study, 3D black-blood MSDE-prep and DIR resulted in similar blood suppression in left ventricle and right ventricle walls but the MSDE-prep had superior myocardial signal and wall sharpness. Conclusion: MSDE-prep allows volumetric black-blood imaging of the heart.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Aug 2012
Externally publishedYes


  • 3D imaging
  • black-blood cardiac imaging
  • motion sensitized driven equilibrium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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