Free-breathing 3 T magnetic resonance T2-mapping of the heart

Ruud B. Van Heeswijk, Hélène Feliciano, Cédric Bongard, Gabriele Bonanno, Simone Coppo, Nathalie Lauriers, Didier Locca, Juerg Schwitter, Matthias Stuber

Research output: Contribution to journalArticle

Abstract

Objectives: This study sought to establish an accurate and reproducible T2-mapping cardiac magnetic resonance (CMR) methodology at 3 T and to evaluate it in healthy volunteers and patients with myocardial infarct. Background: Myocardial edema affects the T2 relaxation time on CMR. Therefore, T2-mapping has been established to characterize edema at 1.5 T. A 3 T implementation designed for longitudinal studies and aimed at guiding and monitoring therapy remains to be implemented, thoroughly characterized, and evaluated in vivo. Methods: A free-breathing navigator-gated radial CMR pulse sequence with an adiabatic T2 preparation module and an empirical fitting equation for T2 quantification was optimized using numerical simulations and was validated at 3 T in a phantom study. Its reproducibility for myocardial T2 quantification was then ascertained in healthy volunteers and improved using an external reference phantom with known T2. In a small cohort of patients with established myocardial infarction, the local T2 value and extent of the edematous region were determined and compared with conventional T2-weighted CMR and x-ray coronary angiography, where available. Results: The numerical simulations and phantom study demonstrated that the empirical fitting equation is significantly more accurate for T2 quantification than that for the more conventional exponential decay. The volunteer study consistently demonstrated a reproducibility error as low as 2 ± 1% using the external reference phantom and an average myocardial T2 of 38.5 ± 4.5 ms. Intraobserver and interobserver variability in the volunteers were -0.04 ± 0.89 ms (p = 0.86) and -0.23 ± 0.91 ms (p = 0.87), respectively. In the infarction patients, the T2 in edema was 62.4 ± 9.2 ms and was consistent with the x-ray angiographic findings. Simultaneously, the extent of the edematous region by T2-mapping correlated well with that from the T2-weighted images (r = 0.91). Conclusions: The new, well-characterized 3 T methodology enables robust and accurate cardiac T 2-mapping at 3 T with high spatial resolution, while the addition of a reference phantom improves reproducibility. This technique may be well suited for longitudinal studies in patients with suspected or established heart disease.

Original languageEnglish (US)
Pages (from-to)1231-1239
Number of pages9
JournalJACC: Cardiovascular Imaging
Volume5
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Respiration
Magnetic Resonance Spectroscopy
Edema
Longitudinal Studies
Volunteers
Healthy Volunteers
Myocardial Infarction
X-Rays
Observer Variation
Coronary Angiography
Infarction
Heart Diseases
Therapeutics

Keywords

  • longitudinal studies
  • myocardial infarction
  • T-mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Van Heeswijk, R. B., Feliciano, H., Bongard, C., Bonanno, G., Coppo, S., Lauriers, N., ... Stuber, M. (2012). Free-breathing 3 T magnetic resonance T2-mapping of the heart. JACC: Cardiovascular Imaging, 5(12), 1231-1239. https://doi.org/10.1016/j.jcmg.2012.06.010

Free-breathing 3 T magnetic resonance T2-mapping of the heart. / Van Heeswijk, Ruud B.; Feliciano, Hélène; Bongard, Cédric; Bonanno, Gabriele; Coppo, Simone; Lauriers, Nathalie; Locca, Didier; Schwitter, Juerg; Stuber, Matthias.

In: JACC: Cardiovascular Imaging, Vol. 5, No. 12, 12.2012, p. 1231-1239.

Research output: Contribution to journalArticle

Van Heeswijk, RB, Feliciano, H, Bongard, C, Bonanno, G, Coppo, S, Lauriers, N, Locca, D, Schwitter, J & Stuber, M 2012, 'Free-breathing 3 T magnetic resonance T2-mapping of the heart', JACC: Cardiovascular Imaging, vol. 5, no. 12, pp. 1231-1239. https://doi.org/10.1016/j.jcmg.2012.06.010
Van Heeswijk RB, Feliciano H, Bongard C, Bonanno G, Coppo S, Lauriers N et al. Free-breathing 3 T magnetic resonance T2-mapping of the heart. JACC: Cardiovascular Imaging. 2012 Dec;5(12):1231-1239. https://doi.org/10.1016/j.jcmg.2012.06.010
Van Heeswijk, Ruud B. ; Feliciano, Hélène ; Bongard, Cédric ; Bonanno, Gabriele ; Coppo, Simone ; Lauriers, Nathalie ; Locca, Didier ; Schwitter, Juerg ; Stuber, Matthias. / Free-breathing 3 T magnetic resonance T2-mapping of the heart. In: JACC: Cardiovascular Imaging. 2012 ; Vol. 5, No. 12. pp. 1231-1239.
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AU - Bongard, Cédric

AU - Bonanno, Gabriele

AU - Coppo, Simone

AU - Lauriers, Nathalie

AU - Locca, Didier

AU - Schwitter, Juerg

AU - Stuber, Matthias

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N2 - Objectives: This study sought to establish an accurate and reproducible T2-mapping cardiac magnetic resonance (CMR) methodology at 3 T and to evaluate it in healthy volunteers and patients with myocardial infarct. Background: Myocardial edema affects the T2 relaxation time on CMR. Therefore, T2-mapping has been established to characterize edema at 1.5 T. A 3 T implementation designed for longitudinal studies and aimed at guiding and monitoring therapy remains to be implemented, thoroughly characterized, and evaluated in vivo. Methods: A free-breathing navigator-gated radial CMR pulse sequence with an adiabatic T2 preparation module and an empirical fitting equation for T2 quantification was optimized using numerical simulations and was validated at 3 T in a phantom study. Its reproducibility for myocardial T2 quantification was then ascertained in healthy volunteers and improved using an external reference phantom with known T2. In a small cohort of patients with established myocardial infarction, the local T2 value and extent of the edematous region were determined and compared with conventional T2-weighted CMR and x-ray coronary angiography, where available. Results: The numerical simulations and phantom study demonstrated that the empirical fitting equation is significantly more accurate for T2 quantification than that for the more conventional exponential decay. The volunteer study consistently demonstrated a reproducibility error as low as 2 ± 1% using the external reference phantom and an average myocardial T2 of 38.5 ± 4.5 ms. Intraobserver and interobserver variability in the volunteers were -0.04 ± 0.89 ms (p = 0.86) and -0.23 ± 0.91 ms (p = 0.87), respectively. In the infarction patients, the T2 in edema was 62.4 ± 9.2 ms and was consistent with the x-ray angiographic findings. Simultaneously, the extent of the edematous region by T2-mapping correlated well with that from the T2-weighted images (r = 0.91). Conclusions: The new, well-characterized 3 T methodology enables robust and accurate cardiac T 2-mapping at 3 T with high spatial resolution, while the addition of a reference phantom improves reproducibility. This technique may be well suited for longitudinal studies in patients with suspected or established heart disease.

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