TY - JOUR
T1 - Framework for Validation and Implementation of In Vitro Toxicity Tests
T2 - Report of the Validation and Technology Transfer Committee of the Johns Hopkins Center for Alternatives to Animal Testing
AU - Goldberg, Alan
AU - Frazier, John M.
AU - Brusick, David
AU - Dickens, Michael S.
AU - Flint, Oliver
AU - Renskers, Kevin J.
AU - Gettings, Stephen D.
AU - Hill, Richard N.
AU - Lipnick, Robert L.
AU - Veronesi, Bellina
AU - Bradlaw, June A.
AU - Green, Sidney
AU - Wilcox, Neil L.
AU - Scala, Robert A.
AU - Curren, Rodger D.
PY - 1993
Y1 - 1993
N2 - In toxicology the development and application of in vitro alternatives to reduce or replace animal testing, or to lessen the distress and discomfort of laboratory animals, is a rapidly developing trend. However, at present there is no formal administrative process to organize, coordinate, or evaluate these activities. A framework capable of fostering the validation of new methods is essential for the effective transfer of new technology from the research laboratory to practical use. This committee has identified four essential validation resources: chemical bank(s), cell and tissue banks, a data bank, and reference laboratories. We recommend the creation of a Scientific Advisory Board of experts in toxicity testing, representing the academic, industrial and regulatory communities. Test validation acceptance is contingent upon broad buy-in by disparate groups in the scientific community: academia, industry and government. We believe that this can be achieved by early and frequent communication among the parties and agreement upon common goals. The committee hopes that the creation of a validation infrastructure built with the elements described in this report will facilitate scientific acceptance and utilization of alternative methodologies and speed implementation of reduction, refinement and replacement alternatives in toxicity testing.
AB - In toxicology the development and application of in vitro alternatives to reduce or replace animal testing, or to lessen the distress and discomfort of laboratory animals, is a rapidly developing trend. However, at present there is no formal administrative process to organize, coordinate, or evaluate these activities. A framework capable of fostering the validation of new methods is essential for the effective transfer of new technology from the research laboratory to practical use. This committee has identified four essential validation resources: chemical bank(s), cell and tissue banks, a data bank, and reference laboratories. We recommend the creation of a Scientific Advisory Board of experts in toxicity testing, representing the academic, industrial and regulatory communities. Test validation acceptance is contingent upon broad buy-in by disparate groups in the scientific community: academia, industry and government. We believe that this can be achieved by early and frequent communication among the parties and agreement upon common goals. The committee hopes that the creation of a validation infrastructure built with the elements described in this report will facilitate scientific acceptance and utilization of alternative methodologies and speed implementation of reduction, refinement and replacement alternatives in toxicity testing.
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U2 - 10.3109/10915819309140619
DO - 10.3109/10915819309140619
M3 - Article
AN - SCOPUS:84973702836
VL - 12
SP - 23
EP - 30
JO - International Journal of Toxicology
JF - International Journal of Toxicology
SN - 1091-5818
IS - 1
ER -