Frailty: An emerging research and clinical paradigm - Issues and controversies

Howard Bergman, Luigi Ferrucci, Jack Guralnik, David B. Hogan, Silvia Hummel, Sathya Karunananthan, Christina Wolfson

Research output: Contribution to journalArticle

Abstract

Clinicians and researchers have shown increasing interest in frailty. Yet, there is still considerable uncertainty regarding the concept and its definition. In this article, we present perspectives on key issues and controversies discussed by scientists from 13 different countries, representing a diverse range of disciplines, at the 2006 Second International Working Meeting on Frailty and Aging. The following fundamental questions are discussed: What is the distinction, if any, between frailty and aging? What is its relationship with chronic disease? Is frailty a syndrome or a series of age-related impairments that predict adverse outcomes? What are the critical domains in its operational definition? Is frailty a useful concept? The implications of different models and approaches are examined. Although consensus has yet to be attained, work accomplished to date has opened exciting new horizons. The article concludes with suggested directions for future research.

Original languageEnglish (US)
Pages (from-to)731-737
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number7
StatePublished - Jul 2007
Externally publishedYes

ASJC Scopus subject areas

  • Aging

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    Bergman, H., Ferrucci, L., Guralnik, J., Hogan, D. B., Hummel, S., Karunananthan, S., & Wolfson, C. (2007). Frailty: An emerging research and clinical paradigm - Issues and controversies. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 62(7), 731-737.