Fragmentation of prostatic needle biopsy cores containing adenocarcinoma: The role of specimen submission

Daniel A. Fajardo, Jonathan Ira Epstein

Research output: Contribution to journalArticle

Abstract

Objective To determine the factors contributing to the fragmentation of prostatic core biopsies containing prostatic carcinoma, which might complicate the quantification of the number cores with cancer and/or the amount of tumour in a core. MATERIALS AND METHODS Prostate biopsy cases containing fragmented cores with cancer and cancer cases present only in unfragmented cores were sought in records from the consultant service of one of the authors. A 'part' corresponded to the site-specific jar submitted by the urologist (i.e. left or right; left apex, left mid, etc.). Cases of prostatic adenocarcinoma with fragmented cores containing cancer (463) and cases with cancer lacking fragmented cores (200) were compared. Results The mean number of parts per case was 8.1 and 7.5 in the unfragmented and fragmented cases, respectively (not significant). The mean number of cores per part was significantly higher in the fragmented group than the unfragmented group (2.6 vs 2.1, P = 0.004). The number of parts containing cancer was higher in cases with fragmented cores than in cases with unfragmented cores (2.8 vs 1.6, P <0.001). A higher mean Gleason score was associated with the cancer in fragmented cores than in unfragmented cores (6.6 vs 6.2, P <0.001). Multivariate regression analysis showed that fragmentation was associated with the number of parts with cancer (P <0.001), cores per part (P <0.001) and Gleason score (P <0.04). CONCLUSIONS The number of parts per case with cancer, number of cores submitted per part, and Gleason score contribute to the likelihood of fragmentation of cores containing prostatic adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalBJU International
Volume105
Issue number2
DOIs
StatePublished - Jan 2010

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Large-Core Needle Biopsy
Adenocarcinoma
Neoplasms
Neoplasm Grading
Biopsy
Consultants
Prostate
Multivariate Analysis
Regression Analysis
Carcinoma

Keywords

  • Cores
  • Gleason score
  • Prostate adenocarcinoma
  • Prostate needle biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Fragmentation of prostatic needle biopsy cores containing adenocarcinoma : The role of specimen submission. / Fajardo, Daniel A.; Epstein, Jonathan Ira.

In: BJU International, Vol. 105, No. 2, 01.2010, p. 172-175.

Research output: Contribution to journalArticle

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abstract = "Objective To determine the factors contributing to the fragmentation of prostatic core biopsies containing prostatic carcinoma, which might complicate the quantification of the number cores with cancer and/or the amount of tumour in a core. MATERIALS AND METHODS Prostate biopsy cases containing fragmented cores with cancer and cancer cases present only in unfragmented cores were sought in records from the consultant service of one of the authors. A 'part' corresponded to the site-specific jar submitted by the urologist (i.e. left or right; left apex, left mid, etc.). Cases of prostatic adenocarcinoma with fragmented cores containing cancer (463) and cases with cancer lacking fragmented cores (200) were compared. Results The mean number of parts per case was 8.1 and 7.5 in the unfragmented and fragmented cases, respectively (not significant). The mean number of cores per part was significantly higher in the fragmented group than the unfragmented group (2.6 vs 2.1, P = 0.004). The number of parts containing cancer was higher in cases with fragmented cores than in cases with unfragmented cores (2.8 vs 1.6, P <0.001). A higher mean Gleason score was associated with the cancer in fragmented cores than in unfragmented cores (6.6 vs 6.2, P <0.001). Multivariate regression analysis showed that fragmentation was associated with the number of parts with cancer (P <0.001), cores per part (P <0.001) and Gleason score (P <0.04). CONCLUSIONS The number of parts per case with cancer, number of cores submitted per part, and Gleason score contribute to the likelihood of fragmentation of cores containing prostatic adenocarcinoma.",
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N2 - Objective To determine the factors contributing to the fragmentation of prostatic core biopsies containing prostatic carcinoma, which might complicate the quantification of the number cores with cancer and/or the amount of tumour in a core. MATERIALS AND METHODS Prostate biopsy cases containing fragmented cores with cancer and cancer cases present only in unfragmented cores were sought in records from the consultant service of one of the authors. A 'part' corresponded to the site-specific jar submitted by the urologist (i.e. left or right; left apex, left mid, etc.). Cases of prostatic adenocarcinoma with fragmented cores containing cancer (463) and cases with cancer lacking fragmented cores (200) were compared. Results The mean number of parts per case was 8.1 and 7.5 in the unfragmented and fragmented cases, respectively (not significant). The mean number of cores per part was significantly higher in the fragmented group than the unfragmented group (2.6 vs 2.1, P = 0.004). The number of parts containing cancer was higher in cases with fragmented cores than in cases with unfragmented cores (2.8 vs 1.6, P <0.001). A higher mean Gleason score was associated with the cancer in fragmented cores than in unfragmented cores (6.6 vs 6.2, P <0.001). Multivariate regression analysis showed that fragmentation was associated with the number of parts with cancer (P <0.001), cores per part (P <0.001) and Gleason score (P <0.04). CONCLUSIONS The number of parts per case with cancer, number of cores submitted per part, and Gleason score contribute to the likelihood of fragmentation of cores containing prostatic adenocarcinoma.

AB - Objective To determine the factors contributing to the fragmentation of prostatic core biopsies containing prostatic carcinoma, which might complicate the quantification of the number cores with cancer and/or the amount of tumour in a core. MATERIALS AND METHODS Prostate biopsy cases containing fragmented cores with cancer and cancer cases present only in unfragmented cores were sought in records from the consultant service of one of the authors. A 'part' corresponded to the site-specific jar submitted by the urologist (i.e. left or right; left apex, left mid, etc.). Cases of prostatic adenocarcinoma with fragmented cores containing cancer (463) and cases with cancer lacking fragmented cores (200) were compared. Results The mean number of parts per case was 8.1 and 7.5 in the unfragmented and fragmented cases, respectively (not significant). The mean number of cores per part was significantly higher in the fragmented group than the unfragmented group (2.6 vs 2.1, P = 0.004). The number of parts containing cancer was higher in cases with fragmented cores than in cases with unfragmented cores (2.8 vs 1.6, P <0.001). A higher mean Gleason score was associated with the cancer in fragmented cores than in unfragmented cores (6.6 vs 6.2, P <0.001). Multivariate regression analysis showed that fragmentation was associated with the number of parts with cancer (P <0.001), cores per part (P <0.001) and Gleason score (P <0.04). CONCLUSIONS The number of parts per case with cancer, number of cores submitted per part, and Gleason score contribute to the likelihood of fragmentation of cores containing prostatic adenocarcinoma.

KW - Cores

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