Fragmentation of carbohydrates in laser desorption, plasma desorption and fast atom bombardment mass spectrometry

William B. Martin; Laurence Silly; Constance M. Murphy; Thomas J. Raley; Robert J. Cotter; Mark F. Bean

doi:10.1016/0168-1176(89)83031-9

Fragmentation of carbohydrates in laser desorption, plasma desorption and fast atom bombardment mass spectrometry

William B. Martin, Laurence Silly, Constance M. Murphy, Thomas J. Raley, Robert J. Cotter, Mark F. Bean

School of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Laser desorption mass spectra of carbohydrates show abundant fragment ions which can be used for structure elucidation. Fragmentation occurs primarily as two-bond ring cleavages, in contrast to the glycosidic bond cleavages observed (often weakly) in fast atom bombardment and plasma desorption mass spectra. Laser desorption can thus provide an alternative to chemical derivatization procedures used to improve fragmentation in these two techniques. In addition, the combination of several ionization techniques can serve to provide a more complete structural picture.

Original language	English (US)
Pages (from-to)	243-265
Number of pages	23
Journal	International Journal of Mass Spectrometry and Ion Processes
Volume	92
Issue number	C
DOIs	https://doi.org/10.1016/0168-1176(89)83031-9
State	Published - Sep 15 1989

ASJC Scopus subject areas

Spectroscopy

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10.1016/0168-1176(89)83031-9

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title = "Fragmentation of carbohydrates in laser desorption, plasma desorption and fast atom bombardment mass spectrometry",

abstract = "Laser desorption mass spectra of carbohydrates show abundant fragment ions which can be used for structure elucidation. Fragmentation occurs primarily as two-bond ring cleavages, in contrast to the glycosidic bond cleavages observed (often weakly) in fast atom bombardment and plasma desorption mass spectra. Laser desorption can thus provide an alternative to chemical derivatization procedures used to improve fragmentation in these two techniques. In addition, the combination of several ionization techniques can serve to provide a more complete structural picture.",

author = "Martin, {William B.} and Laurence Silly and Murphy, {Constance M.} and Raley, {Thomas J.} and Cotter, {Robert J.} and Bean, {Mark F.}",

note = "Funding Information: This work was supported by grants (DCB 85-09638, BBS 86-10589 and BBS 85-15390) from the National Science Foundation, and carried out at the Middle Atlantic Mass Spectrometry Laboratory, an NSF Shared Instrumentation Facility.",

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TY - JOUR

T1 - Fragmentation of carbohydrates in laser desorption, plasma desorption and fast atom bombardment mass spectrometry

AU - Martin, William B.

AU - Silly, Laurence

AU - Murphy, Constance M.

AU - Raley, Thomas J.

AU - Cotter, Robert J.

AU - Bean, Mark F.

N1 - Funding Information: This work was supported by grants (DCB 85-09638, BBS 86-10589 and BBS 85-15390) from the National Science Foundation, and carried out at the Middle Atlantic Mass Spectrometry Laboratory, an NSF Shared Instrumentation Facility.

PY - 1989/9/15

Y1 - 1989/9/15

N2 - Laser desorption mass spectra of carbohydrates show abundant fragment ions which can be used for structure elucidation. Fragmentation occurs primarily as two-bond ring cleavages, in contrast to the glycosidic bond cleavages observed (often weakly) in fast atom bombardment and plasma desorption mass spectra. Laser desorption can thus provide an alternative to chemical derivatization procedures used to improve fragmentation in these two techniques. In addition, the combination of several ionization techniques can serve to provide a more complete structural picture.

AB - Laser desorption mass spectra of carbohydrates show abundant fragment ions which can be used for structure elucidation. Fragmentation occurs primarily as two-bond ring cleavages, in contrast to the glycosidic bond cleavages observed (often weakly) in fast atom bombardment and plasma desorption mass spectra. Laser desorption can thus provide an alternative to chemical derivatization procedures used to improve fragmentation in these two techniques. In addition, the combination of several ionization techniques can serve to provide a more complete structural picture.

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Fragmentation of carbohydrates in laser desorption, plasma desorption and fast atom bombardment mass spectrometry

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