Fragile X: Translation in action

Mark F. Bear, Gül Dölen, Emily Osterweil, Naveen Nagarajan

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


Fragile X is a synapsopathy - a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only for human fragile X but also for autism and mental retardation of unknown etiology.

Original languageEnglish (US)
Pages (from-to)84-87
Number of pages4
Issue number1
StatePublished - Jan 2008


  • Autism
  • Cerebral protein synthesis
  • Developmental disorder
  • Fragile x
  • Metabotropic glutamate receptor
  • Synaptic plasticity

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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