Fracture tolerance related to skeletal development and aging throughout life: 3-point bending of human femurs

Jason L. Forman, Eduardo Del Pozo De Dios, Ioannis Symeonidis, Julio Duart, Jason R. Kerrigan, Robert S. Salzar, Sriram Balasubramanian, Maria Segui-gomez, Richard W. Kent

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study investigated the mechanical factors contributing to changes in fracture tolerance of the femur throughout skeletal development, maturity and advanced age. A database was compiled from the literature describing dynamic three-point bending tolerances of cadaver femurs. This database was augmented with 23 new tests targeting pediatric and young adult ages (median age of new tests: 27 years). For a subset of specimens an analytical model was developed to decompose the observed changes with age into contributing geometric and material factors. The resulting aggregated dataset included tests on 83 specimens, with an age range of 16 months to 83 years. The fracture moments ranged from 20 Nm (for a pediatric specimen) to 630 Nm (for an adult male). The data showed a rapid increase in fracture moment during skeletal development with a plateau or peak during adulthood (approximately 25-45 years). This was followed by a general decrease in fracture moment in advanced age. Decomposition of these trends suggests that the increase in strength through skeletal development was attributable to geometric changes. The decrease in fracture moment in advanced age was likely due to decreases in cortical thickness combined with other factors, possibly including a decrease in cortical bone ultimate stress.

Original languageEnglish (US)
Title of host publication2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury
Pages524-539
Number of pages16
StatePublished - 2012
Externally publishedYes
Event2012 International Research Council on the Biomechanics of Injury Conference, IRCOBI 2012 - Dublin, Ireland
Duration: Sep 12 2012Sep 14 2012

Other

Other2012 International Research Council on the Biomechanics of Injury Conference, IRCOBI 2012
CountryIreland
CityDublin
Period9/12/129/14/12

Fingerprint

tolerance
Aging of materials
Pediatrics
Set theory
Analytical models
Bone
maturity
Decomposition
adulthood
young adult
trend

Keywords

  • Aging
  • Development
  • Femur
  • Fracture
  • Pediatric

ASJC Scopus subject areas

  • Biomedical Engineering
  • Human Factors and Ergonomics

Cite this

Forman, J. L., De Dios, E. D. P., Symeonidis, I., Duart, J., Kerrigan, J. R., Salzar, R. S., ... Kent, R. W. (2012). Fracture tolerance related to skeletal development and aging throughout life: 3-point bending of human femurs. In 2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury (pp. 524-539)

Fracture tolerance related to skeletal development and aging throughout life : 3-point bending of human femurs. / Forman, Jason L.; De Dios, Eduardo Del Pozo; Symeonidis, Ioannis; Duart, Julio; Kerrigan, Jason R.; Salzar, Robert S.; Balasubramanian, Sriram; Segui-gomez, Maria; Kent, Richard W.

2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury. 2012. p. 524-539.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Forman, JL, De Dios, EDP, Symeonidis, I, Duart, J, Kerrigan, JR, Salzar, RS, Balasubramanian, S, Segui-gomez, M & Kent, RW 2012, Fracture tolerance related to skeletal development and aging throughout life: 3-point bending of human femurs. in 2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury. pp. 524-539, 2012 International Research Council on the Biomechanics of Injury Conference, IRCOBI 2012, Dublin, Ireland, 9/12/12.
Forman JL, De Dios EDP, Symeonidis I, Duart J, Kerrigan JR, Salzar RS et al. Fracture tolerance related to skeletal development and aging throughout life: 3-point bending of human femurs. In 2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury. 2012. p. 524-539
Forman, Jason L. ; De Dios, Eduardo Del Pozo ; Symeonidis, Ioannis ; Duart, Julio ; Kerrigan, Jason R. ; Salzar, Robert S. ; Balasubramanian, Sriram ; Segui-gomez, Maria ; Kent, Richard W. / Fracture tolerance related to skeletal development and aging throughout life : 3-point bending of human femurs. 2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury. 2012. pp. 524-539
@inproceedings{ffaca025f96d49839af74b2de43695d1,
title = "Fracture tolerance related to skeletal development and aging throughout life: 3-point bending of human femurs",
abstract = "This study investigated the mechanical factors contributing to changes in fracture tolerance of the femur throughout skeletal development, maturity and advanced age. A database was compiled from the literature describing dynamic three-point bending tolerances of cadaver femurs. This database was augmented with 23 new tests targeting pediatric and young adult ages (median age of new tests: 27 years). For a subset of specimens an analytical model was developed to decompose the observed changes with age into contributing geometric and material factors. The resulting aggregated dataset included tests on 83 specimens, with an age range of 16 months to 83 years. The fracture moments ranged from 20 Nm (for a pediatric specimen) to 630 Nm (for an adult male). The data showed a rapid increase in fracture moment during skeletal development with a plateau or peak during adulthood (approximately 25-45 years). This was followed by a general decrease in fracture moment in advanced age. Decomposition of these trends suggests that the increase in strength through skeletal development was attributable to geometric changes. The decrease in fracture moment in advanced age was likely due to decreases in cortical thickness combined with other factors, possibly including a decrease in cortical bone ultimate stress.",
keywords = "Aging, Development, Femur, Fracture, Pediatric",
author = "Forman, {Jason L.} and {De Dios}, {Eduardo Del Pozo} and Ioannis Symeonidis and Julio Duart and Kerrigan, {Jason R.} and Salzar, {Robert S.} and Sriram Balasubramanian and Maria Segui-gomez and Kent, {Richard W.}",
year = "2012",
language = "English (US)",
pages = "524--539",
booktitle = "2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury",

}

TY - GEN

T1 - Fracture tolerance related to skeletal development and aging throughout life

T2 - 3-point bending of human femurs

AU - Forman, Jason L.

AU - De Dios, Eduardo Del Pozo

AU - Symeonidis, Ioannis

AU - Duart, Julio

AU - Kerrigan, Jason R.

AU - Salzar, Robert S.

AU - Balasubramanian, Sriram

AU - Segui-gomez, Maria

AU - Kent, Richard W.

PY - 2012

Y1 - 2012

N2 - This study investigated the mechanical factors contributing to changes in fracture tolerance of the femur throughout skeletal development, maturity and advanced age. A database was compiled from the literature describing dynamic three-point bending tolerances of cadaver femurs. This database was augmented with 23 new tests targeting pediatric and young adult ages (median age of new tests: 27 years). For a subset of specimens an analytical model was developed to decompose the observed changes with age into contributing geometric and material factors. The resulting aggregated dataset included tests on 83 specimens, with an age range of 16 months to 83 years. The fracture moments ranged from 20 Nm (for a pediatric specimen) to 630 Nm (for an adult male). The data showed a rapid increase in fracture moment during skeletal development with a plateau or peak during adulthood (approximately 25-45 years). This was followed by a general decrease in fracture moment in advanced age. Decomposition of these trends suggests that the increase in strength through skeletal development was attributable to geometric changes. The decrease in fracture moment in advanced age was likely due to decreases in cortical thickness combined with other factors, possibly including a decrease in cortical bone ultimate stress.

AB - This study investigated the mechanical factors contributing to changes in fracture tolerance of the femur throughout skeletal development, maturity and advanced age. A database was compiled from the literature describing dynamic three-point bending tolerances of cadaver femurs. This database was augmented with 23 new tests targeting pediatric and young adult ages (median age of new tests: 27 years). For a subset of specimens an analytical model was developed to decompose the observed changes with age into contributing geometric and material factors. The resulting aggregated dataset included tests on 83 specimens, with an age range of 16 months to 83 years. The fracture moments ranged from 20 Nm (for a pediatric specimen) to 630 Nm (for an adult male). The data showed a rapid increase in fracture moment during skeletal development with a plateau or peak during adulthood (approximately 25-45 years). This was followed by a general decrease in fracture moment in advanced age. Decomposition of these trends suggests that the increase in strength through skeletal development was attributable to geometric changes. The decrease in fracture moment in advanced age was likely due to decreases in cortical thickness combined with other factors, possibly including a decrease in cortical bone ultimate stress.

KW - Aging

KW - Development

KW - Femur

KW - Fracture

KW - Pediatric

UR - http://www.scopus.com/inward/record.url?scp=84867767919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867767919&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84867767919

SP - 524

EP - 539

BT - 2012 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury

ER -