TY - JOUR
T1 - Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system
AU - Triant, Virginia A.
AU - Brown, Todd T.
AU - Lee, Hang
AU - Grinspoon, Steven K.
N1 - Funding Information:
This work was supported in part by Grants T32 AI07387 (to V.A.T., Massachusetts General Hospital), K23 AT002862 (to T.T.B., Johns Hopkins Medical Center), and K24 DK064545 (to S.K.G., Massachusetts General Hospital).
PY - 2008/9
Y1 - 2008/9
N2 - Context: Reduced bone mineral density has been demonstrated among HIV-infected patients, but fracture prevalence is unknown. Objective: The objective of the study was to compare fracture prevalence in HIV-infected and non-HIV-infected patients. Design: This was a population-based study. Setting: The study was conducted at a large U.S. health care system. Patients: A total of 8525 HIV-infected and 2,208,792 non-HIV-infected patients with at least one inpatient or outpatient encounter between October 1, 1996, and March 21, 2008, was compared. Main Outcome Measure: Fracture prevalence using specific International Classification of Diseases, Ninth Revision, Clinical Modification fracture codes was measured. Results: The overall fracture prevalence was 2.87 vs. 1.77 patients with fractures per 100 persons in HIV-infected, compared with non-HIV-infected patients (P < 0.0001). Among females, the overall fracture prevalence was 2.49 vs. 1.72 per 100 persons in HIV-infected vs. non-HIV-infected patients (P = 0.002). HIV-infected females had a higher prevalence of vertebral (0.81 vs. 0.45; P = 0.01) and wrist (1.31 vs. 0.83; P = 0.01) fractures per 100 persons, compared with non-HIV-infected females but had a similar prevalence of hip fractures (0.47 vs. 0.56; P = 0.53). Among males, the fracture prevalence per 100 persons was higher in HIV-infected vs. non-HIV-infected patients for any fracture (3.08 vs. 1.83; P < 0.0001), vertebral fractures (1.03 vs. 0.49; P < 0.0001), hip fractures (0.79 vs. 0.45; P = 0.001), and wrist fractures (1.46 vs. 0.99; P = 0.001). Fracture prevalence was higher relative to non-HIV-infected patients among African-American and Caucasian females and Caucasian males. Conclusions: Fracture prevalence is increased in HIV-infected compared with non-HIV-infected patients.
AB - Context: Reduced bone mineral density has been demonstrated among HIV-infected patients, but fracture prevalence is unknown. Objective: The objective of the study was to compare fracture prevalence in HIV-infected and non-HIV-infected patients. Design: This was a population-based study. Setting: The study was conducted at a large U.S. health care system. Patients: A total of 8525 HIV-infected and 2,208,792 non-HIV-infected patients with at least one inpatient or outpatient encounter between October 1, 1996, and March 21, 2008, was compared. Main Outcome Measure: Fracture prevalence using specific International Classification of Diseases, Ninth Revision, Clinical Modification fracture codes was measured. Results: The overall fracture prevalence was 2.87 vs. 1.77 patients with fractures per 100 persons in HIV-infected, compared with non-HIV-infected patients (P < 0.0001). Among females, the overall fracture prevalence was 2.49 vs. 1.72 per 100 persons in HIV-infected vs. non-HIV-infected patients (P = 0.002). HIV-infected females had a higher prevalence of vertebral (0.81 vs. 0.45; P = 0.01) and wrist (1.31 vs. 0.83; P = 0.01) fractures per 100 persons, compared with non-HIV-infected females but had a similar prevalence of hip fractures (0.47 vs. 0.56; P = 0.53). Among males, the fracture prevalence per 100 persons was higher in HIV-infected vs. non-HIV-infected patients for any fracture (3.08 vs. 1.83; P < 0.0001), vertebral fractures (1.03 vs. 0.49; P < 0.0001), hip fractures (0.79 vs. 0.45; P = 0.001), and wrist fractures (1.46 vs. 0.99; P = 0.001). Fracture prevalence was higher relative to non-HIV-infected patients among African-American and Caucasian females and Caucasian males. Conclusions: Fracture prevalence is increased in HIV-infected compared with non-HIV-infected patients.
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U2 - 10.1210/jc.2008-0828
DO - 10.1210/jc.2008-0828
M3 - Article
C2 - 18593764
AN - SCOPUS:51649122545
SN - 0021-972X
VL - 93
SP - 3499
EP - 3504
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -