Foxp3, Regulatory T Cell, and Autoimmune Diseases

Jin Hui Tao, Miao Cheng, Jiang Ping Tang, Qin Liu, Fan Pan, Xiang Pei Li

Research output: Contribution to journalArticle

Abstract

Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other autoimmune diseases. Therefore, therapeutic modulation of Tregs could be a potent means of treating autoimmune diseases. Human Tregs are diverse, however, and not all of them have immunosuppressive effects. Forkhead box P3 (Foxp3), a pivotal transcription factor of Tregs that is crucial in maintaining Treg immunosuppressive function, can be expressed heterogeneously or unstably across Treg subpopulations. Insights into modulating Treg differentiation on the level of DNA transcription or protein modification may improve the success of Treg modifying immunotherapies. In this review, we will summarize three main prospects: the regulatory mechanism of Foxp3, the influence on Foxp3 and Tregs in autoimmune diseases, then finally, how Tregs can be used to treat autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalInflammation
DOIs
StateAccepted/In press - Nov 24 2016

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Regulatory T-Lymphocytes
Autoimmune Diseases
Immunosuppressive Agents
Immune Tolerance
Systemic Lupus Erythematosus
Immunotherapy
Immune System
Rheumatoid Arthritis
Homeostasis
Transcription Factors
DNA
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tao, J. H., Cheng, M., Tang, J. P., Liu, Q., Pan, F., & Li, X. P. (2016). Foxp3, Regulatory T Cell, and Autoimmune Diseases. Inflammation, 1-12. DOI: 10.1007/s10753-016-0470-8

Foxp3, Regulatory T Cell, and Autoimmune Diseases. / Tao, Jin Hui; Cheng, Miao; Tang, Jiang Ping; Liu, Qin; Pan, Fan; Li, Xiang Pei.

In: Inflammation, 24.11.2016, p. 1-12.

Research output: Contribution to journalArticle

Tao, JH, Cheng, M, Tang, JP, Liu, Q, Pan, F & Li, XP 2016, 'Foxp3, Regulatory T Cell, and Autoimmune Diseases' Inflammation, pp. 1-12. DOI: 10.1007/s10753-016-0470-8
Tao JH, Cheng M, Tang JP, Liu Q, Pan F, Li XP. Foxp3, Regulatory T Cell, and Autoimmune Diseases. Inflammation. 2016 Nov 24;1-12. Available from, DOI: 10.1007/s10753-016-0470-8

Tao, Jin Hui; Cheng, Miao; Tang, Jiang Ping; Liu, Qin; Pan, Fan; Li, Xiang Pei / Foxp3, Regulatory T Cell, and Autoimmune Diseases.

In: Inflammation, 24.11.2016, p. 1-12.

Research output: Contribution to journalArticle

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