Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes

Elizabeth A. Newman, Dong Won Kim, Jun Wan, Jie Wang, Jiang Qian, Seth Blackshaw

Research output: Contribution to journalArticlepeer-review

Abstract

Although the hypothalamus functions as a master homeostat for many behaviors, little is known about the transcriptional networks that control its development. To investigate this question, we analyzed mice deficient for the Forkhead domain transcription factor Foxd1. Foxd1 is selectively expressed in neuroepithelial cells of the prethalamus and hypothalamus prior to the onset of neurogenesis, and is later restricted to neural progenitors of the prethalamus and anterior hypothalamus. During early stages of neurogenesis, we observed that Foxd1-deficient mice showed reduced expression of Six3 and Vax1 in anterior hypothalamus, but overall patterning of the prethalamus and hypothalamus is unaffected. After neurogenesis is complete, however, a progressive reduction and eventual loss of expression of molecular markers of the suprachiasmatic, paraventricular and periventricular hypothalamic is observed. These findings demonstrate that Foxd1 acts in hypothalamic progenitors to allow sustained expression of a subset of genes selectively expressed in mature neurons of the anterior hypothalamus.

Original languageEnglish (US)
Pages (from-to)102-111
Number of pages10
JournalDevelopmental biology
Volume439
Issue number2
DOIs
StatePublished - Jul 15 2018

Keywords

  • Cell fate
  • Development
  • Hypothalamus
  • Neuroendocrine
  • Paraventricular
  • Patterning
  • Prethalamus
  • Suprachiasmatic

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes'. Together they form a unique fingerprint.

Cite this