Foveal thickening in retinitis pigmentosa patients with cystoid macular edema

Mahnaz Shahidi, Gerald Fishman, Yuichiro Ogura, Karl Ambroz, Ran Zeimer

Research output: Contribution to journalArticle

Abstract

Purpose: Clinical evaluation of cystoid macular edema (CME), known to occur in patients with retinitis pigmentosa (RP), is based on the presence of vascular leakage on fluorescein angiography. Due to an inability to quantitatively assess retinal thickening, the degree of thickening from fluid accumulation and its relation to fluorescein dye leakage into the extravascular retinal space has not been established. The relationship between fluorescein dye leakage and foveal thickening and the effect of methazolamide treatment was studied. Methods: The retinal thickness analyzer was used to measure the degree of thickening in six patients with RP and CME. A laser beam was projected at an oblique angle to the retina, and images of the intersection of the laser slit with the anterior and posterior retinal surfaces were recorded. The digitized images were analyzed using a dedicated software program to provide quantitative measurements of retinal thickness. Routine fluorescein angiography was performed. Results: The amount of fluorescein dye leakage was not indicative of the degree of retinal thickening due to fluid accumulation. Foveal thickening and fluorescein dye leakage were reduced in five of six eyes after methazolamide treatment. Eyes with moderate thickening reversed to normal, whereas eyes with severe thickening showed only a minimal reduction in thickness. Concuslon: Retinal thickness measurement is a useful method of evaluating both the extent of and changes in retinal thickness after carbonic anhydrase treatment.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalRetina
Volume14
Issue number3
StatePublished - 1994

Fingerprint

Retinitis Pigmentosa
Macular Edema
Fluorescein
Methazolamide
Coloring Agents
Fluorescein Angiography
Lasers
Carbonic Anhydrases
Blood Vessels
Retina
Therapeutics
Software

Keywords

  • Cystoid macular edema
  • Fluorescein leakage
  • Foveal thickening
  • Methazolamide treatment
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Shahidi, M., Fishman, G., Ogura, Y., Ambroz, K., & Zeimer, R. (1994). Foveal thickening in retinitis pigmentosa patients with cystoid macular edema. Retina, 14(3), 243-247.

Foveal thickening in retinitis pigmentosa patients with cystoid macular edema. / Shahidi, Mahnaz; Fishman, Gerald; Ogura, Yuichiro; Ambroz, Karl; Zeimer, Ran.

In: Retina, Vol. 14, No. 3, 1994, p. 243-247.

Research output: Contribution to journalArticle

Shahidi, M, Fishman, G, Ogura, Y, Ambroz, K & Zeimer, R 1994, 'Foveal thickening in retinitis pigmentosa patients with cystoid macular edema', Retina, vol. 14, no. 3, pp. 243-247.
Shahidi M, Fishman G, Ogura Y, Ambroz K, Zeimer R. Foveal thickening in retinitis pigmentosa patients with cystoid macular edema. Retina. 1994;14(3):243-247.
Shahidi, Mahnaz ; Fishman, Gerald ; Ogura, Yuichiro ; Ambroz, Karl ; Zeimer, Ran. / Foveal thickening in retinitis pigmentosa patients with cystoid macular edema. In: Retina. 1994 ; Vol. 14, No. 3. pp. 243-247.
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