Fourth ventricular thyrotropin induces satiety and increases body temperature in rats

Ulrika Smedh, Karen A. Scott, Timothy H Moran

Research output: Contribution to journalArticle

Abstract

Besides its wellknown action to stimulate thyroid hormone release, thyrotropin mRNA is expressed within the brain, and thyrotropin and its receptor have been shown to be present in brain areas that control feeding and gastrointestinal function. Here, the hypothesis that thyrotropin acts on receptors in the hindbrain to alter food intake and/or gastric function was tested. Fourth ventricular injections of thyrotropin (0.06, 0.60, and 6.00 μg) were given to rats with chronic intracerebroventricular cannulas aimed at the fourth ventricle. Thyrotropin produced an acute reduction of sucrose intake (30 min). The highest dose of thyrotropin caused inhibition of overnight solid food intake (22 h). In contrast, subcutaneous administration of corresponding thyrotropin doses had no effect on nutrient intake. The highest effective dose of fourth ventricular thyrotropin (6 μg) did not produce a conditioned flavor avoidance in a standardized two-bottle test, nor did it affect water intake or gastric emptying of glucose. Thyrotropin injected in the fourth ventricle produced a small but significant increase in rectal temperature and lowered plasma levels of tri-iodothyronin but did not affect plasma levels of thyroxine. In addition, there was a tendency toward a reduction in blood glucose 2 h after fourth ventricular thyrotropin injection (P = 0.056). In conclusion, fourth ventricular thyrotropin specifically inhibits food intake, increases core temperature, and lowers plasma levels of tri-iodothyronin but does not affect gastromotor function.

Original languageEnglish (US)
Pages (from-to)R734-R740
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume314
Issue number5
DOIs
StatePublished - May 1 2018

Fingerprint

Thyrotropin
Body Temperature
Fourth Ventricle
Eating
Thyrotropin Receptors
Rhombencephalon
Injections
Temperature
Gastric Emptying
Brain
Thyroxine
Thyroid Hormones
Drinking
Sucrose
Blood Glucose
Stomach
Glucose
Food
Messenger RNA

Keywords

  • Conditioned flavor avoidance
  • Ingestive behavior
  • Thyroid- stimulating hormone
  • Thyrotropin
  • Tri-iodothyronine
  • Water intake

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Fourth ventricular thyrotropin induces satiety and increases body temperature in rats. / Smedh, Ulrika; Scott, Karen A.; Moran, Timothy H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 314, No. 5, 01.05.2018, p. R734-R740.

Research output: Contribution to journalArticle

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