TY - JOUR
T1 - Four-year weight losses in the look AHEAD study
T2 - Factors associated with long-term success
AU - the Look AHEAD Research Group
AU - Wadden, Thomas A.
AU - Neiberg, Rebecca H.
AU - Wing, Rena R.
AU - Clark, Jeanne M.
AU - Delahanty, Linda M.
AU - Hill, James O.
AU - Krakoff, Jonathan
AU - Otto, Amy
AU - Ryan, Donna H.
AU - Vitolins, Mara Z.
AU - Brancati, Frederick L.
AU - Swartz, Lee
AU - Cheskin, Lawrence
AU - Clark, Jeanne M.
AU - Stewart, Kerry
AU - Rubin, Richard
AU - Arceci, Jean
AU - Bau, Suzanne
AU - Charleston, Jeanne
AU - Diggins, Danielle
AU - Johnson, Mia
AU - Lambert, Joyce
AU - Michalski, Kathy
AU - Niggetts, Daron
AU - Sapun, Chanchai
AU - Bray, George A.
AU - Rau, Kristi
AU - Strate, Allison
AU - Greenway, Frank L.
AU - Ryan, Donna H.
AU - Williamson, Donald
AU - Armand, Brandi
AU - Arceneaux, Jennifer
AU - Bachand, Amy
AU - Begnaud, Michelle
AU - Berhard, Betsy
AU - Caderette, Elizabeth
AU - Cerniauskas, Barbara
AU - Creel, David
AU - Crow, Diane
AU - Duncan, Crystal
AU - Guay, Helen
AU - Johnson, Carolyn
AU - Kora, Nancy
AU - LaFleur, Kelly
AU - Landry, Kim
AU - Lingle, Missy
AU - Perault, Jennifer
AU - Puckett, Cindy
AU - Shipp, Mandy
PY - 2011/10/1
Y1 - 2011/10/1
N2 - This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P 0.0001). More ILI than DSE participants lost 5% (46% vs. 25%, P 0.0001) and 10% (23% vs. 10%, P 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.
AB - This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P 0.0001). More ILI than DSE participants lost 5% (46% vs. 25%, P 0.0001) and 10% (23% vs. 10%, P 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.
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UR - http://www.scopus.com/inward/citedby.url?scp=80053273586&partnerID=8YFLogxK
U2 - 10.1038/oby.2011.230
DO - 10.1038/oby.2011.230
M3 - Article
C2 - 21779086
AN - SCOPUS:80053273586
SN - 1930-7381
VL - 19
SP - 1987
EP - 1998
JO - Obesity
JF - Obesity
IS - 10
ER -