Four-year weight losses in the look AHEAD study

Factors associated with long-term success

Thomas A. Wadden, Rebecca H. Neiberg, Rena R. Wing, Jeanne Clark, Linda M. Delahanty, James O. Hill, Jonathan Krakoff, Amy Otto, Donna H. Ryan, Kerry Stewart

Research output: Contribution to journalArticle

Abstract

This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P 0.0001). More ILI than DSE participants lost 5% (46% vs. 25%, P 0.0001) and 10% (23% vs. 10%, P 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.

Original languageEnglish (US)
Pages (from-to)1987-1998
Number of pages12
JournalObesity
Volume19
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Life Style
Weight Loss
Health
Education
Type 2 Diabetes Mellitus
Weights and Measures
Eating
Exercise
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Four-year weight losses in the look AHEAD study : Factors associated with long-term success. / Wadden, Thomas A.; Neiberg, Rebecca H.; Wing, Rena R.; Clark, Jeanne; Delahanty, Linda M.; Hill, James O.; Krakoff, Jonathan; Otto, Amy; Ryan, Donna H.; Stewart, Kerry.

In: Obesity, Vol. 19, No. 10, 10.2011, p. 1987-1998.

Research output: Contribution to journalArticle

Wadden, TA, Neiberg, RH, Wing, RR, Clark, J, Delahanty, LM, Hill, JO, Krakoff, J, Otto, A, Ryan, DH & Stewart, K 2011, 'Four-year weight losses in the look AHEAD study: Factors associated with long-term success', Obesity, vol. 19, no. 10, pp. 1987-1998. https://doi.org/10.1038/oby.2011.230
Wadden, Thomas A. ; Neiberg, Rebecca H. ; Wing, Rena R. ; Clark, Jeanne ; Delahanty, Linda M. ; Hill, James O. ; Krakoff, Jonathan ; Otto, Amy ; Ryan, Donna H. ; Stewart, Kerry. / Four-year weight losses in the look AHEAD study : Factors associated with long-term success. In: Obesity. 2011 ; Vol. 19, No. 10. pp. 1987-1998.
@article{a35ca693886f49478f4405ab4640f820,
title = "Four-year weight losses in the look AHEAD study: Factors associated with long-term success",
abstract = "This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7{\%} of initial weight, compared with 1.1{\%} for DSE (P 0.0001). More ILI than DSE participants lost 5{\%} (46{\%} vs. 25{\%}, P 0.0001) and 10{\%} (23{\%} vs. 10{\%}, P 0.0001) of initial weight. Within the ILI, achievement of both the 5{\%} and 10{\%} categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost 10{\%} at year 1, of whom 374 (42.2{\%}) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., 5{\%}) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45{\%} of patients at 4 years.",
author = "Wadden, {Thomas A.} and Neiberg, {Rebecca H.} and Wing, {Rena R.} and Jeanne Clark and Delahanty, {Linda M.} and Hill, {James O.} and Jonathan Krakoff and Amy Otto and Ryan, {Donna H.} and Kerry Stewart",
year = "2011",
month = "10",
doi = "10.1038/oby.2011.230",
language = "English (US)",
volume = "19",
pages = "1987--1998",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Four-year weight losses in the look AHEAD study

T2 - Factors associated with long-term success

AU - Wadden, Thomas A.

AU - Neiberg, Rebecca H.

AU - Wing, Rena R.

AU - Clark, Jeanne

AU - Delahanty, Linda M.

AU - Hill, James O.

AU - Krakoff, Jonathan

AU - Otto, Amy

AU - Ryan, Donna H.

AU - Stewart, Kerry

PY - 2011/10

Y1 - 2011/10

N2 - This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P 0.0001). More ILI than DSE participants lost 5% (46% vs. 25%, P 0.0001) and 10% (23% vs. 10%, P 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.

AB - This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P 0.0001). More ILI than DSE participants lost 5% (46% vs. 25%, P 0.0001) and 10% (23% vs. 10%, P 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.

UR - http://www.scopus.com/inward/record.url?scp=80053273586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053273586&partnerID=8YFLogxK

U2 - 10.1038/oby.2011.230

DO - 10.1038/oby.2011.230

M3 - Article

VL - 19

SP - 1987

EP - 1998

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 10

ER -