Four classes of HERV-K long terminal repeats and their relative promoter strengths for transcription

David E. Mold, Tzyy Choou Wu, Frederic Askin, Ru Chih C. Huang

Research output: Contribution to journalArticlepeer-review

Abstract

The human genome contains abundant copies of HERV-K endogenous retro- virus sequences. These remnants of ancient infection have the potential to reshape the genome by retrotransposition or infection since they are highly expressed in cells of germ line origin. When conserved nucleotide sequence variations in the U3 region of the HERV-K 3' LTR were used to distinguish between individual HERV-K proviruses, 4 major classes of HERV-K LTRs were identified. HERV-K U3 regions from the different classes were compared in an in vitro transcription assay and were found to vary significantly in their promoter activities.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalJournal of biomedical science
Volume4
Issue number2-3
DOIs
StatePublished - Mar 1997

Keywords

  • Human endogenous retrovirus
  • In vitro transcription
  • LTR U3 DNA sequence

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Four classes of HERV-K long terminal repeats and their relative promoter strengths for transcription'. Together they form a unique fingerprint.

Cite this