Abstract
The human genome contains abundant copies of HERV-K endogenous retro- virus sequences. These remnants of ancient infection have the potential to reshape the genome by retrotransposition or infection since they are highly expressed in cells of germ line origin. When conserved nucleotide sequence variations in the U3 region of the HERV-K 3' LTR were used to distinguish between individual HERV-K proviruses, 4 major classes of HERV-K LTRs were identified. HERV-K U3 regions from the different classes were compared in an in vitro transcription assay and were found to vary significantly in their promoter activities.
Original language | English (US) |
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Pages (from-to) | 78-82 |
Number of pages | 5 |
Journal | Journal of biomedical science |
Volume | 4 |
Issue number | 2-3 |
DOIs | |
State | Published - Mar 1997 |
Keywords
- Human endogenous retrovirus
- In vitro transcription
- LTR U3 DNA sequence
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
- Biochemistry, medical
- Pharmacology (medical)