Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

Liang Zhang; Huanyu Wang; Tianshu Yang; Zhifeng Su; Dan Fang; Yafeng Wang; Jiazhu Fang; Xinwei Hou; Yingying Le; Keqiang Chen; Ji Ming Wang; Shao Bo Su; Qing Lin; Qi Zhou

doi:10.1080/2162402X.2015.1078055

Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

Liang Zhang, Huanyu Wang, Tianshu Yang, Zhifeng Su, Dan Fang, Yafeng Wang, Jiazhu Fang, Xinwei Hou, Yingying Le, Keqiang Chen, Ji Ming Wang, Shao Bo Su, Qing Lin, Qi Zhou

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.

Original language	English (US)
Journal	OncoImmunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1080/2162402X.2015.1078055
State	Published - Feb 1 2016

Keywords

Cancer
GPCR
HepG2
IL-8
liver

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2015.1078055

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title = "Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells",

abstract = "G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.",

keywords = "Cancer, GPCR, HepG2, IL-8, liver",

author = "Liang Zhang and Huanyu Wang and Tianshu Yang and Zhifeng Su and Dan Fang and Yafeng Wang and Jiazhu Fang and Xinwei Hou and Yingying Le and Keqiang Chen and Wang, {Ji Ming} and Su, {Shao Bo} and Qing Lin and Qi Zhou",

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year = "2016",

month = feb,

day = "1",

doi = "10.1080/2162402X.2015.1078055",

language = "English (US)",

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T1 - Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

AU - Zhang, Liang

AU - Wang, Huanyu

AU - Yang, Tianshu

AU - Su, Zhifeng

AU - Fang, Dan

AU - Wang, Yafeng

AU - Fang, Jiazhu

AU - Hou, Xinwei

AU - Le, Yingying

AU - Chen, Keqiang

AU - Wang, Ji Ming

AU - Su, Shao Bo

AU - Lin, Qing

AU - Zhou, Qi

PY - 2016/2/1

Y1 - 2016/2/1

N2 - G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.

AB - G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.

KW - Cancer

KW - GPCR

KW - HepG2

KW - IL-8

KW - liver

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Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

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