Formation of regulatory patterns during signal propagation in a mammalian cellular network

Avi Ma'ayan; Sherry L. Jenkins; Susana Neves; Anthony Hasseldine; Elizabeth Grace; Benjamin Dubin-Thaler; Narat J. Eungdamrong; Gehzi Weng; Prahlad T. Ram; J. Jeremy Rice; Aaron Kershenbaum; Gustavo A. Stolovitzky; Robert D. Blitzer; Ravi Iyengar

doi:10.1126/science.1108876

Formation of regulatory patterns during signal propagation in a mammalian cellular network

Avi Ma'ayan, Sherry L. Jenkins, Susana Neves, Anthony Hasseldine, Elizabeth Grace, Benjamin Dubin-Thaler, Narat J. Eungdamrong, Gehzi Weng, Prahlad T. Ram, J. Jeremy Rice, Aaron Kershenbaum, Gustavo A. Stolovitzky, Robert D. Blitzer, Ravi Iyengar

Whiting School of Engineering

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Abstract

We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.

Original language	English (US)
Pages (from-to)	1078-1083
Number of pages	6
Journal	Science
Volume	309
Issue number	5737
DOIs	https://doi.org/10.1126/science.1108876
State	Published - Aug 12 2005

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Ma'ayan, A., Jenkins, S. L., Neves, S., Hasseldine, A., Grace, E., Dubin-Thaler, B., Eungdamrong, N. J., Weng, G., Ram, P. T., Rice, J. J., Kershenbaum, A., Stolovitzky, G. A., Blitzer, R. D., & Iyengar, R. (2005). Formation of regulatory patterns during signal propagation in a mammalian cellular network. Science, 309(5737), 1078-1083. https://doi.org/10.1126/science.1108876

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abstract = "We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.",

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AU - Ma'ayan, Avi

AU - Jenkins, Sherry L.

AU - Neves, Susana

AU - Hasseldine, Anthony

AU - Grace, Elizabeth

AU - Dubin-Thaler, Benjamin

AU - Eungdamrong, Narat J.

AU - Weng, Gehzi

AU - Ram, Prahlad T.

AU - Rice, J. Jeremy

AU - Kershenbaum, Aaron

AU - Stolovitzky, Gustavo A.

AU - Blitzer, Robert D.

AU - Iyengar, Ravi

PY - 2005/8/12

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Formation of regulatory patterns during signal propagation in a mammalian cellular network

Abstract

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