TY - JOUR
T1 - Formation of regulatory patterns during signal propagation in a mammalian cellular network
AU - Ma'ayan, Avi
AU - Jenkins, Sherry L.
AU - Neves, Susana
AU - Hasseldine, Anthony
AU - Grace, Elizabeth
AU - Dubin-Thaler, Benjamin
AU - Eungdamrong, Narat J.
AU - Weng, Gehzi
AU - Ram, Prahlad T.
AU - Rice, J. Jeremy
AU - Kershenbaum, Aaron
AU - Stolovitzky, Gustavo A.
AU - Blitzer, Robert D.
AU - Iyengar, Ravi
PY - 2005/8/12
Y1 - 2005/8/12
N2 - We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.
AB - We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.
UR - http://www.scopus.com/inward/record.url?scp=23644437498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23644437498&partnerID=8YFLogxK
U2 - 10.1126/science.1108876
DO - 10.1126/science.1108876
M3 - Article
C2 - 16099987
AN - SCOPUS:23644437498
VL - 309
SP - 1078
EP - 1083
JO - Science
JF - Science
SN - 0036-8075
IS - 5737
ER -