Formation of regulatory patterns during signal propagation in a mammalian cellular network

Avi Ma'ayan, Sherry L. Jenkins, Susana Neves, Anthony Hasseldine, Elizabeth Grace, Benjamin Dubin-Thaler, Narat J. Eungdamrong, Gehzi Weng, Prahlad T. Ram, J. Jeremy Rice, Aaron Kershenbaum, Gustavo A. Stolovitzky, Robert D. Blitzer, Ravi Iyengar

Research output: Contribution to journalArticlepeer-review

Abstract

We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.

Original languageEnglish (US)
Pages (from-to)1078-1083
Number of pages6
JournalScience
Volume309
Issue number5737
DOIs
StatePublished - Aug 12 2005

ASJC Scopus subject areas

  • General

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