Abstract
The effect of ingesting charcoal-broiled (CB) beef on polycydic aromatic hydrocarbon (PAH)-DNA adduct levels in nucleated peripheral white blood cells (WBCs) was examined in four healthy, non-smoking males who consumed an average of 280 g CD beef daily for 7 days. PAM-DNA adducts were quantitated by enzyme-linked immunosorbent assay. During the week of CB beef consumption, two individuals exhibited a 3- to 6-fold increase in PAH-DNA adducts above baseline levels observed during the month prior to CD beef consumption. un contrast, PAM-DNA adduct levels in the two other subjects did not increase. Thus, dietary sources of PAH can contribute to the PAH-DNA adduct load in peripheral WBCs in some individuals.
Original language | English (US) |
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Pages (from-to) | 1241-1243 |
Number of pages | 3 |
Journal | Carcinogenesis |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1990 |
ASJC Scopus subject areas
- Cancer Research