Formation of idiopathic macular hole-reappraisal

Po Ting Yeh, Ta Ching Chen, Chang Hao Yang, Tzyy Chang Ho, Muh Shy Chen, Jen Shang Huang, Chung May Yang

Research output: Contribution to journalArticlepeer-review


Purpose: The study is intended to examine the development of macular hole in idiopathic conditions. Methods: A 2-year case file of optical coherence tomography (OCT) with the initial diagnosis of idiopathic impending hole (IH) or lamellar hole (LH) was reviewed. All cases of IH or LH were sequentially examined for more than 9 months. All cases with IH had vitreo-foveal adhesion, and were separated into type A (foveal detachment ± inner retinal cysts) and type B (inner retinal cysts only). Results: Eight cases had type A IH, 15 cases had type B IH, and 27 cases had LH. Seven cases of type A IH developed full-thickness macular hole (FTMH) at an average of 5.1±2.2 months, and the one other case was operated. Five cases of type B IH were operated. For the other ten cases, at an average of 11.4±3.5 months, none had developed foveal detachment or FTMH, but five had developed LH. Three cases with initial LH subsequently developed FTMH. Conclusion: In idiopathic cases, vitreo-foveal traction with foveal detachment may lead to FHMH, while inner cysts only without foveal detachment seem tend to evolve into LH instead of FHMH. Furthermore, LH may develop into FTMH.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number6
StatePublished - Feb 2 2010


  • Foveal detachment
  • Full thickness macular hole
  • Impending hole
  • Lamellar hole

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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