TY - JOUR
T1 - Formation of direct-acting genotoxic substances in nitrosated smoked fish and meat products
T2 - Identification of simple phenolic precursors and phenyldiazonium ions as reactive products
AU - Ohshima, H.
AU - Friesen, M.
AU - Malaveille, C.
AU - Brouet, I.
AU - Hautefeuille, A.
AU - Bartsch, H.
PY - 1989
Y1 - 1989
N2 - Epidemiological studies have associated the consumption of smoked fish and meat products with an increased risk of stomach cancer. Therefore, the reaction of such smoked foods with nitrite under acidic conditions was investigated and was shown to produce potent direct-acting genotoxic substances as detected by the SOS Chromotest. Similar genotoxic activity was observed in nitrosated samples of wood-smoke condensates. Simple phenolic compounds such as phenol, 3-methoxycatechol, catechol and vanillin were identified as the precursors of the genotoxic substances. These phenolic compounds also exhibited direct-acting genotoxicity after nitrosation. The major genotoxic substances formed after nitrosation of phenol were isolated and identified as 4- and 2-hydroxyphenyldiazonium ions. Nitrosation of various wood-smoke condensates was found to generate the same type of diazonium compounds, which in part account for the genotoxicity of nitrosated smoked foods.
AB - Epidemiological studies have associated the consumption of smoked fish and meat products with an increased risk of stomach cancer. Therefore, the reaction of such smoked foods with nitrite under acidic conditions was investigated and was shown to produce potent direct-acting genotoxic substances as detected by the SOS Chromotest. Similar genotoxic activity was observed in nitrosated samples of wood-smoke condensates. Simple phenolic compounds such as phenol, 3-methoxycatechol, catechol and vanillin were identified as the precursors of the genotoxic substances. These phenolic compounds also exhibited direct-acting genotoxicity after nitrosation. The major genotoxic substances formed after nitrosation of phenol were isolated and identified as 4- and 2-hydroxyphenyldiazonium ions. Nitrosation of various wood-smoke condensates was found to generate the same type of diazonium compounds, which in part account for the genotoxicity of nitrosated smoked foods.
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U2 - 10.1016/0278-6915(89)90069-0
DO - 10.1016/0278-6915(89)90069-0
M3 - Article
C2 - 2731816
AN - SCOPUS:0024392247
SN - 0278-6915
VL - 27
SP - 193
EP - 203
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 3
ER -