Formation and selection of intergenogroup reassortants during cell culture adaptation of rotaviruses from dually infected subjects

R. L. Ward, O. Nakagomi, D. R. Knowlton, M. M. McNeal, T. Nakagomi, N. Huda, J. D. Clemens, D. A. Sack

Research output: Contribution to journalComment/debatepeer-review

Abstract

A previous study showed that intergenogroup reassortants of human rotaviruses can persist in nature (R. L. Ward, O. Nakagomi, D. R. Knowlton, M. M. McNeal, T. Nakagomi, J. D. Clemens, D. A. Sack, and G. M. Schiff, J. Virol. 64:3219-3225, 1990), but the mechanisms involved in their formation and selection had not been determined. In this study it was shown that, during cell culture adaptation of rotaviruses belonging to different genogroups from stools of dually infected subjects, intergenogroup reassortants were formed and selected, presumably mimicking the processes that occur in nature.

Original languageEnglish (US)
Pages (from-to)2699-2701
Number of pages3
JournalJournal of virology
Volume65
Issue number5
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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