Formation and Selection of Intergenogroup Reassortants during Cell Culture Adaptation of Rotaviruses from Dually Infected Subjects

Richard L. Ward; Osamu Nakagomi; Douglas R. Knowlton; Monica M. McNeal; Toyoko Nakagomi; Nural Huda; John D. Clemens; David A. Sack

Formation and Selection of Intergenogroup Reassortants during Cell Culture Adaptation of Rotaviruses from Dually Infected Subjects

Richard L. Ward, Osamu Nakagomi, Douglas R. Knowlton, Monica M. McNeal, Toyoko Nakagomi, Nural Huda, John D. Clemens, David A. Sack

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A previous study showed that intergenogroup reassortants of human rotaviruses can persist in nature (R. L. Ward, O. Nakagomi, D. R. Knowlton, M. M. McNeal, T. Nakagomi, J. D. Clemens, D. A. Sack, and G. M. Schiff, J. Virol. 64:3219-3225, 1990), but the mechanisms involved in their formation and selection had not been determined. In this study it was shown that, during cell culture adaptation of rotaviruses belonging to different genogroups from stools of dually infected subjects, intergenogroup reassortants were formed and selected, presumably mimicking the processes that occur in nature.

Original language	English (US)
Pages (from-to)	2699-2701
Number of pages	3
Journal	Journal of virology
Volume	65
Issue number	5
State	Published - May 1991

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Cite this

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title = "Formation and Selection of Intergenogroup Reassortants during Cell Culture Adaptation of Rotaviruses from Dually Infected Subjects",

abstract = "A previous study showed that intergenogroup reassortants of human rotaviruses can persist in nature (R. L. Ward, O. Nakagomi, D. R. Knowlton, M. M. McNeal, T. Nakagomi, J. D. Clemens, D. A. Sack, and G. M. Schiff, J. Virol. 64:3219-3225, 1990), but the mechanisms involved in their formation and selection had not been determined. In this study it was shown that, during cell culture adaptation of rotaviruses belonging to different genogroups from stools of dually infected subjects, intergenogroup reassortants were formed and selected, presumably mimicking the processes that occur in nature.",

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AU - Ward, Richard L.

AU - Nakagomi, Osamu

AU - Knowlton, Douglas R.

AU - McNeal, Monica M.

AU - Nakagomi, Toyoko

AU - Huda, Nural

AU - Clemens, John D.

AU - Sack, David A.

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Formation and Selection of Intergenogroup Reassortants during Cell Culture Adaptation of Rotaviruses from Dually Infected Subjects

Abstract

ASJC Scopus subject areas

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