Formation and repair of interstrand cross-links in DNA

David M. Noll, Tracey McGregor Mason, Paul S. Miller

Research output: Contribution to journalArticle

Abstract

A better understanding of the mechanisms of DNA interstrand cross-link repair can lead to more effective strategies for the treatment of cancer and/or the design of drugs that produce interstrand crosslinks that can evade repair. This review focuses on DNA interstrand crosslinks for which there is a substantial body of information about their repair. These include interstrand cross-links produced by nitrogen mustards, mitomycin C, platinum compounds and psoralen. First, the formation and structures of these crosslinks are described. Second, the mechanism of repair of these cross-links as derived from both genetic studies and experiments in cell-free systems is discussed as they occur in both prokaryotic and eukaryotic organisms.

Original languageEnglish (US)
Pages (from-to)277-301
Number of pages25
JournalChemical Reviews
Volume106
Issue number2
DOIs
StatePublished - Feb 2006

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Repair
DNA
Platinum Compounds
Ficusin
Mechlorethamine
Mitomycin
Pharmaceutical Preparations
Experiments

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Noll, D. M., McGregor Mason, T., & Miller, P. S. (2006). Formation and repair of interstrand cross-links in DNA. Chemical Reviews, 106(2), 277-301. https://doi.org/10.1021/cr040478b

Formation and repair of interstrand cross-links in DNA. / Noll, David M.; McGregor Mason, Tracey; Miller, Paul S.

In: Chemical Reviews, Vol. 106, No. 2, 02.2006, p. 277-301.

Research output: Contribution to journalArticle

Noll, DM, McGregor Mason, T & Miller, PS 2006, 'Formation and repair of interstrand cross-links in DNA', Chemical Reviews, vol. 106, no. 2, pp. 277-301. https://doi.org/10.1021/cr040478b
Noll, David M. ; McGregor Mason, Tracey ; Miller, Paul S. / Formation and repair of interstrand cross-links in DNA. In: Chemical Reviews. 2006 ; Vol. 106, No. 2. pp. 277-301.
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