@article{fa58d2c0dd1849dcaf25442c5638339a,
title = "Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release",
abstract = "Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.",
keywords = "activity dependence, dendrite formation, glutamate release, glutamate uncaging, spine formation, synaptogenesis",
author = "Albrecht Sigler and Oh, {Won Chan} and Cordelia Imig and Bekir Altas and Hiroshi Kawabe and Cooper, {Benjamin H.} and Kwon, {Hyung Bae} and Rhee, {Jeong Seop} and Nils Brose",
note = "Funding Information: This work was supported by the Max Planck Society (to H.B.K., J.S.R, and N.B.), the German Research Foundation (SFB889/B1 to J.S.R. and N.B. and CNMPB FZT103 to N.B.), the European Union (ERC Advanced Grant “SynPrime” to N.B.), the Max Planck Florida Institute for Neuroscience (to H.B.K.), and the NIH (R01 MH107460 to H.B.K.). We thank Sabine Bolte and Anja G{\"u}nther for excellent technical support, the MPIEM Animal Facility for mouse husbandry, and the MPIEM DNA Core Facility for mouse genotyping. A.S. is employed by Science Products GmbH. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = apr,
day = "19",
doi = "10.1016/j.neuron.2017.03.029",
language = "English (US)",
volume = "94",
pages = "304--311.e4",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}