Forensic drug testing for opiates. VII. Urinary excretion profile of intranasal (snorted) heroin

Edward J. Cone, Rebecca Jufer, William D. Darwin, Saul B. Needleman

Research output: Contribution to journalArticle

Abstract

The urinary excretion profile of free and conjugated morphine and 6- acetylmorphine was determined by gas chromatography-mass spectrometry (GC- MS) and immunoassay for six healthy male subjects after intranasal administration of 6 and 12 mg of heroin HCI. Results were compared with heroin administration (6 mg) by the intramuscular route. Heroin metabolites were rapidly excreted with peak concentrations appearing in the first or second specimen collection after drug administration. Concentrations of total morphine and 6-acetylmorphine after intranasal heroin were similar to those after intramuscular administration, but free morphine concentrations after the lower intranasal dose were significantly lower than the same dose given intramuscularly. Detection times for total morphine by GC-MS and immunoassay (300-ng/mL cutoff concentration) were generally 24-36 h, but were reduced to less than 12 h at the higher cutoff concentration of 2000 ng/mL. 6- Acetylmorphine concentrations were highly variable and short-lived; detection times (10 ng/mL) were approximately 2-3 h for most subjects, but some failed to produce positive specimens. Of 14 specimens with 6-acetylmorphine concentrations of 10 ng/mL or more, ten were associated with total morphine concentrations greater than 2000 ng/mL, and four specimens had total morphine concentrations less than 2000 ng/mL. Overall, intranasal administration of heroin produced a similar profile of excretion of heroin metabolites to intramuscular administration.

Original languageEnglish (US)
Pages (from-to)379-392
Number of pages14
JournalJournal of Analytical Toxicology
Volume20
Issue number6
StatePublished - Oct 1996

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Opiate Alkaloids
Heroin
excretion
Morphine
drug
Testing
Pharmaceutical Preparations
Intranasal Administration
immunoassay
Metabolites
Immunoassay
metabolite
Specimen Handling
Human computer interaction
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
gas chromatography
Healthy Volunteers
mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Cone, E. J., Jufer, R., Darwin, W. D., & Needleman, S. B. (1996). Forensic drug testing for opiates. VII. Urinary excretion profile of intranasal (snorted) heroin. Journal of Analytical Toxicology, 20(6), 379-392.

Forensic drug testing for opiates. VII. Urinary excretion profile of intranasal (snorted) heroin. / Cone, Edward J.; Jufer, Rebecca; Darwin, William D.; Needleman, Saul B.

In: Journal of Analytical Toxicology, Vol. 20, No. 6, 10.1996, p. 379-392.

Research output: Contribution to journalArticle

Cone, EJ, Jufer, R, Darwin, WD & Needleman, SB 1996, 'Forensic drug testing for opiates. VII. Urinary excretion profile of intranasal (snorted) heroin', Journal of Analytical Toxicology, vol. 20, no. 6, pp. 379-392.
Cone, Edward J. ; Jufer, Rebecca ; Darwin, William D. ; Needleman, Saul B. / Forensic drug testing for opiates. VII. Urinary excretion profile of intranasal (snorted) heroin. In: Journal of Analytical Toxicology. 1996 ; Vol. 20, No. 6. pp. 379-392.
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