Force interval relationship (FIR) related to the global function of the left ventricle: a computer study

R. Beyar, D. Burkhoff, S. Sideman

Research output: Contribution to journalArticle

Abstract

A model which relates the left ventricular (LV) geometry, structure and sarcomere properties to its global function, recently proposed by the authors, is extended to account for contractility changes which are a function of the heart rate, prematurity of the beat and calcium transients within the cell. To characterise LV function and relate it to fibre function under varying rhythm conditions, a model of muscle force restitution, based on calcium kinetics, was used to calculate the maximum fibre stress at the optimum sarcomere length σ0 as the parameter which depends on the heart rate, the test pulse interval TPI, the action potential duration APD and the restitution time constant. The global LV force interval relationship FIR was then calculated, and by comparing the calculated FIR to the experimental measurement (in dogs) at the ventricular level, the constants of the restitution of force at the fibre level were derived. Based on these constants, the LV function under ejecting conditions at various rhythm disturbances was calculated and related to the local, distributed parameters. This approach provides a tool to describe ventricular function as well as transmural distribution of stress and sarcomere length at a wide variety of loading and rhythm conditions based on given 'muscle level' parameters.

Original languageEnglish (US)
Pages (from-to)446-456
Number of pages11
JournalMedical & Biological Engineering & Computing
Volume28
Issue number5
DOIs
StatePublished - Sep 1990
Externally publishedYes

Keywords

  • Calcium kinetics
  • Force interval relationship
  • Left ventricle
  • Model

ASJC Scopus subject areas

  • Health Information Management
  • Health Informatics
  • Biomedical Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

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