TY - JOUR
T1 - Food intake in baboons
T2 - Effects of a long-acting cholecystokinin analog
AU - Foltin, Richard W.
AU - Moran, Timothy H.
N1 - Funding Information:
This research was supported by DA-4130 from The National Institute on Drug Abuse, and DK-19302 from The National Institute on Health. The assistance of Nondita Bhaduri, James Thomas, Maryanne Byrne, and Drs Thomas Kelly and Marian Fischman is gratefully acknowledged. We also wish to thank Dr T. K. Sawyer at Upjohn Co. for providing the CCK analog U-67827E.
PY - 1989/4
Y1 - 1989/4
N2 - Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e. a meal, became available under the second "consumption component" during which each response produced a 1-g food pellet. After a 10-min interval in which no response occurred, the consumption component was terminated. A long-acting cholecystokinin (CCK) analog U-67827E (U-67: 0.80-3.2 μg/kg) was administered, in the thigh muscle, at 1100 hrs immediately prior to the start of the daily session on Tuesdays and Fridays. U-67 significantly reduced intake during the first 8-h of the session, and intake during the entire 22-h session. The decreased intake was due to a significant decrease in the size of the first meal of the session as a consequence of decreased duration of feeding without a change in response rate. U-67 also produced dose-dependent increases in latency to the first meal of up to 2.5 h. These results demonstrate that a long-acting CCK analog decreases food intake over a prolonged period of time in a naturalistic feeding situation. In addition, the effects of U-67 were limited to the consumption component, suggesting that this CCK analog affected food intake by interacting with physiological mechanisms specifically associated with feeding.
AB - Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e. a meal, became available under the second "consumption component" during which each response produced a 1-g food pellet. After a 10-min interval in which no response occurred, the consumption component was terminated. A long-acting cholecystokinin (CCK) analog U-67827E (U-67: 0.80-3.2 μg/kg) was administered, in the thigh muscle, at 1100 hrs immediately prior to the start of the daily session on Tuesdays and Fridays. U-67 significantly reduced intake during the first 8-h of the session, and intake during the entire 22-h session. The decreased intake was due to a significant decrease in the size of the first meal of the session as a consequence of decreased duration of feeding without a change in response rate. U-67 also produced dose-dependent increases in latency to the first meal of up to 2.5 h. These results demonstrate that a long-acting CCK analog decreases food intake over a prolonged period of time in a naturalistic feeding situation. In addition, the effects of U-67 were limited to the consumption component, suggesting that this CCK analog affected food intake by interacting with physiological mechanisms specifically associated with feeding.
UR - http://www.scopus.com/inward/record.url?scp=0024323684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024323684&partnerID=8YFLogxK
U2 - 10.1016/0195-6663(89)90103-7
DO - 10.1016/0195-6663(89)90103-7
M3 - Article
C2 - 2764555
AN - SCOPUS:0024323684
SN - 0195-6663
VL - 12
SP - 145
EP - 152
JO - Appetite
JF - Appetite
IS - 2
ER -