TY - JOUR
T1 - Follow Your Nose
T2 - Repeat Nasal Bone Evaluation in First-Trimester Screening for Down Syndrome
AU - Miller, Kristen A.
AU - Sagaser, Katelynn G.
AU - Hertenstein, Christine B.
AU - Blakemore, Karin J.
AU - Forster, Katherine R.
AU - Lawson, Cathleen Schmearer
AU - Jelin, Angie C.
N1 - Funding Information:
ACJ is funded by grant K23DK119949 from the National Institutes of Health (NIH). The contents of the publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2023 American Institute of Ultrasound in Medicine.
PY - 2023
Y1 - 2023
N2 - Objective: Examine whether repeat nasal bone evaluation following an absent/uncertain nasal bone on first-trimester screening (FTS) improves Down syndrome (DS) screening specificity. Methods: A retrospective chart review of FTS sonograms in one center from January 2015 to January 2018 was performed. Data was extracted for those with an absent/uncertain nasal bone. Repeat evaluations were offered. Results: Of 6780 FTS sonograms, 589 (8.7%) had an absent/uncertain nasal bone. Upon repeat exam, 268/376 (71.3%) had a present nasal bone. Compared with Black patients, patients of other ethnicities were more likely to have a present nasal bone on exam 2 (P <.00001). Of 268 patients with a present nasal bone on exam 2, 37 (13.8%) had an abnormal DS risk following exam 1; 34/37 (91.9%) normalized following nasal bone visualization, dropping the screen positive rate to 1.1%. Conclusion: Repeat nasal bone examination is beneficial in refining DS risk assessment and improves the specificity of FTS.
AB - Objective: Examine whether repeat nasal bone evaluation following an absent/uncertain nasal bone on first-trimester screening (FTS) improves Down syndrome (DS) screening specificity. Methods: A retrospective chart review of FTS sonograms in one center from January 2015 to January 2018 was performed. Data was extracted for those with an absent/uncertain nasal bone. Repeat evaluations were offered. Results: Of 6780 FTS sonograms, 589 (8.7%) had an absent/uncertain nasal bone. Upon repeat exam, 268/376 (71.3%) had a present nasal bone. Compared with Black patients, patients of other ethnicities were more likely to have a present nasal bone on exam 2 (P <.00001). Of 268 patients with a present nasal bone on exam 2, 37 (13.8%) had an abnormal DS risk following exam 1; 34/37 (91.9%) normalized following nasal bone visualization, dropping the screen positive rate to 1.1%. Conclusion: Repeat nasal bone examination is beneficial in refining DS risk assessment and improves the specificity of FTS.
KW - Down syndrome screening
KW - first-trimester screening
KW - nuchal translucency ultrasound
KW - prenatal ultrasound
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U2 - 10.1002/jum.16190
DO - 10.1002/jum.16190
M3 - Article
C2 - 36744578
AN - SCOPUS:85147513979
SN - 0278-4297
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
ER -