THERAPIEKONTROLLE UNTER THEOPHYLLIN IN ABENDLICHER DOSIERUNG BEI PATIENTEN MIT SCHLAFBEZOGENEN ATMUNGSSTORUNGEN (SBAS) - VERLAUFSBEOBACHTUNG

Translated title of the contribution: Follow-up during theophyllin treatment with daily evening dose in patients with sleep related breathing disorders

E. Grieger, H. Schneider, U. Weichler, J. H. Peter, P. von Wichert, K. Voigt

Research output: Contribution to journalArticle

Abstract

We conducted a prospective study to perform classification according to responder types and follow-up during theophyllin treatment (500 mg/d) in a group of (up to now) 65 patients suffering from sleep apnoea. Changes in the apnoea index (AI) and clinical symptoms were taken as response criteria. A significant AI reduction was seen during a follow-up period of 3 months. At the last control measurement after 6 months no significant change has been detected so far. 10 patients were classified as Type I responders (improvement in initial AI 60%, over the total period at least 25%). No patient had a responder type II profile. 13 patients were non-responders (improvement in initial AI and over the whole period not more than 25%, no improvement in the pattern of clinical symptoms). 13 patients dropped out of the trial due to non-compliance. Side effects typical of theophylline leading to discontinuation of the treatment course occurred in 5 patients. 22 Patients have not yet completed the course at the time of writing. Standardised questioning of patients showed a definite improvement in feeling tone, especially with regard to the tendency to fall asleep during the day and refreshed feeling in the morning. Nocturnal complaints occurred in only a few isolated cases. However, administration of theophyllin retard preparations in evening doses of 500 mg/d remains a meaningful therapeutic approach to sleep apnoea.

Original languageGerman
Pages (from-to)166-169
Number of pages4
JournalPneumologie
Volume47
Issue numberSUPPL. 1
StatePublished - Jan 1 1993

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Grieger, E., Schneider, H., Weichler, U., Peter, J. H., von Wichert, P., & Voigt, K. (1993). THERAPIEKONTROLLE UNTER THEOPHYLLIN IN ABENDLICHER DOSIERUNG BEI PATIENTEN MIT SCHLAFBEZOGENEN ATMUNGSSTORUNGEN (SBAS) - VERLAUFSBEOBACHTUNG. Pneumologie, 47(SUPPL. 1), 166-169.