Follicle-stimulating hormone receptor in gynecological cancers

Hyun Hoon Chung, Joo Chang Lee, Il Minn

Research output: Contribution to journalReview article

Abstract

Expression of follicle-stimulating hormone receptor (FSHR) is normally restricted to the ovary and the testis, where FSH-dependent cell differentiation occurs. FSHR also is involved in the regulation of angiogenesis in ovary. Expression of FSHR has been consistently shown in vascular endothelial cells of human malignant tumors although biological functions of FSHR on tumor neovasculature have not been fully understood. FSHR expression in vasculature of normal or inflammatory tissues is scarce, suggesting its potential role as a diagnostic and therapeutic target in cancer. FSHR has recently been tested as an imaging biomarker for ovarian cancer as FSHR is found to be over-expressed on ovarian tumors. In addition, FSHR is involved in signaling cascades that mediate cancer progression and metastases. Targeting FSHR could provide new agents as imaging and interventional probes not only for ovarian cancer but also many other human solid cancers. In this review, the expression and potential roles of FSHR in human cancers with emphasis on gynecological cancers will be discussed.

Original languageEnglish (US)
JournalMolecular and Cellular Toxicology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Follicle-stimulating hormone receptor
  • Gynecological cancer
  • Imaging
  • Targeting
  • Therapy
  • Tumor neovasculature

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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