Folic acid for the prevention of neural tube defects

F. Desposito, C. Cunniff, J. L. Frias, S. R. Panny, T. L. Trotter, R. S. Wappner, J. W. Hanson, S. Elias, C. A. Moore, M. Lloyd-Puryear, F. De la Cruz, B. A. Pletcher, S. Cho

Research output: Contribution to journalReview articlepeer-review


The American Academy of Pediatrics endorses the US Public Health Service (USPHS) recommendation that all women capable of becoming pregnant consume 400 μg of folic acid daily to prevent neural tube defects (NTDs). Studies have demonstrated that periconceptional folic acid supplementation can prevent 50% or more of NTDs such as spina bifida and anencephaly. For women who have previously had an NTD-affected pregnancy, the Centers for Disease Control and Prevention (CDC) recommends increasing the intake of folic acid to 4000 μg per day beginning at least 1 month before conception and continuing through the first trimester. Implementation of these recommendations is essential for the primary prevention of these serious and disabling birth defects. Because fewer than 1 in 3 women consume the amount of folic acid recommended by the USPHS, the Academy notes that the prevention of NTDs depends on an urgent and effective campaign to close this prevention gap.

Original languageEnglish (US)
Pages (from-to)325-327
Number of pages3
Issue number2 I
StatePublished - Aug 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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