Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

Mark P. Mattson, Thomas B. Shea

Research output: Contribution to journalArticle

Abstract

Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine - a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis. Dietary folate is required for normal development of the nervous system, playing important roles regulating neurogenesis and programmed cell death. Recent epidemiological and experimental studies have linked folate deficiency and resultant increased homocysteine levels with several neurodegenerative conditions, including stroke, Alzheimer's disease and Parkinson's disease. Moreover, genetic and clinical data suggest roles for folate and homocysteine in the pathogenesis of psychiatric disorders. A better understanding of the roles of folate and homocysteine in neuronal homeostasis throughout life is revealing novel approaches for preventing and treating neurological disorders.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalTrends in Neurosciences
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Neuronal Plasticity
Homocysteine
Folic Acid
Neurodegenerative Diseases
Sulfur Amino Acids
Neurogenesis
Nervous System Diseases
Nervous System
Parkinson Disease
Psychiatry
Epidemiologic Studies
Alzheimer Disease
Oxidative Stress
Homeostasis
Cell Death
Carbon
Stroke
Apoptosis
DNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. / Mattson, Mark P.; Shea, Thomas B.

In: Trends in Neurosciences, Vol. 26, No. 3, 01.03.2003, p. 137-146.

Research output: Contribution to journalArticle

Mattson, Mark P. ; Shea, Thomas B. / Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. In: Trends in Neurosciences. 2003 ; Vol. 26, No. 3. pp. 137-146.
@article{6ab185131b664b01a0ca2e04f24201d6,
title = "Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders",
abstract = "Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine - a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis. Dietary folate is required for normal development of the nervous system, playing important roles regulating neurogenesis and programmed cell death. Recent epidemiological and experimental studies have linked folate deficiency and resultant increased homocysteine levels with several neurodegenerative conditions, including stroke, Alzheimer's disease and Parkinson's disease. Moreover, genetic and clinical data suggest roles for folate and homocysteine in the pathogenesis of psychiatric disorders. A better understanding of the roles of folate and homocysteine in neuronal homeostasis throughout life is revealing novel approaches for preventing and treating neurological disorders.",
author = "Mattson, {Mark P.} and Shea, {Thomas B.}",
year = "2003",
month = "3",
day = "1",
doi = "10.1016/S0166-2236(03)00032-8",
language = "English (US)",
volume = "26",
pages = "137--146",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

AU - Mattson, Mark P.

AU - Shea, Thomas B.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine - a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis. Dietary folate is required for normal development of the nervous system, playing important roles regulating neurogenesis and programmed cell death. Recent epidemiological and experimental studies have linked folate deficiency and resultant increased homocysteine levels with several neurodegenerative conditions, including stroke, Alzheimer's disease and Parkinson's disease. Moreover, genetic and clinical data suggest roles for folate and homocysteine in the pathogenesis of psychiatric disorders. A better understanding of the roles of folate and homocysteine in neuronal homeostasis throughout life is revealing novel approaches for preventing and treating neurological disorders.

AB - Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine - a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis. Dietary folate is required for normal development of the nervous system, playing important roles regulating neurogenesis and programmed cell death. Recent epidemiological and experimental studies have linked folate deficiency and resultant increased homocysteine levels with several neurodegenerative conditions, including stroke, Alzheimer's disease and Parkinson's disease. Moreover, genetic and clinical data suggest roles for folate and homocysteine in the pathogenesis of psychiatric disorders. A better understanding of the roles of folate and homocysteine in neuronal homeostasis throughout life is revealing novel approaches for preventing and treating neurological disorders.

UR - http://www.scopus.com/inward/record.url?scp=0037364417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037364417&partnerID=8YFLogxK

U2 - 10.1016/S0166-2236(03)00032-8

DO - 10.1016/S0166-2236(03)00032-8

M3 - Article

C2 - 12591216

AN - SCOPUS:0037364417

VL - 26

SP - 137

EP - 146

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 3

ER -