Focal transient lesions of the corpus callosum in systemic lupus erythematosus

Simone Appenzeller, Andreia Vasconcellos Faria, Roberto Marini, Lilian Tereza Lavras Costallat, Fernando Cendes

Research output: Contribution to journalArticle

Abstract

Focal lesions limited to the splenium of the corpus callosum are rare and little is known about their etiology. We describe three patients with systemic lupus erythematosus (SLE) that presented transient lesions of the corpus callosum. We reviewed three patients with SLE whose magnetic resonance imaging (MRI) results revealed focal lesions in the splenum of corpus callosum. The medical records, including clinical, serological, and treatment features, were reviewed to determine the etiology of these lesions. Of 115 patients who had MRI for research purposes, three patients with focal nonhemorrhagic lesions of the corpus callosum were identified. All patients had active SLE at the time of MRI. One patient had other findings on MRI, including cerebral venous thrombosis. On follow-up MRI, patients had an inactive disease and the corpus callosum lesions disappeared. A transient lesion in the splenium of corpus callosum seems to be a nonspecific endpoint of different disease processes leading to vasogenic edema. The complete and rapid reversibility in all cases with disease control is emphasized and any invasive diagnostic or therapeutic approach is discouraged.

Original languageEnglish (US)
Pages (from-to)568-571
Number of pages4
JournalClinical Rheumatology
Volume25
Issue number4
DOIs
StatePublished - Jul 2006
Externally publishedYes

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Corpus Callosum
Systemic Lupus Erythematosus
Magnetic Resonance Imaging
Intracranial Thrombosis
Venous Thrombosis
Medical Records
Edema
Therapeutics
Research

Keywords

  • Corpus callosum
  • SLE
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Focal transient lesions of the corpus callosum in systemic lupus erythematosus. / Appenzeller, Simone; Faria, Andreia Vasconcellos; Marini, Roberto; Costallat, Lilian Tereza Lavras; Cendes, Fernando.

In: Clinical Rheumatology, Vol. 25, No. 4, 07.2006, p. 568-571.

Research output: Contribution to journalArticle

Appenzeller, Simone ; Faria, Andreia Vasconcellos ; Marini, Roberto ; Costallat, Lilian Tereza Lavras ; Cendes, Fernando. / Focal transient lesions of the corpus callosum in systemic lupus erythematosus. In: Clinical Rheumatology. 2006 ; Vol. 25, No. 4. pp. 568-571.
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