Focal glomerulosclerosis and erythrocytosis

D. I. Myers, A. A. Ciuffo, C. R. Cooke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A 22-year-old black male presented with erythrocytosis and proteinuria. The erythrocytosis was characterized by increased red cell mass, normal arterial oxygen saturation, and normal hemoglobin electrophoresis and oxygen affinity. There was no splenomegaly, and the white blood cell count, platelet count, serum uric acid concentration, serum B12 levels and leukocyte alkaline phosphatase activity were normal. Tumors of the liver, lung, kidney and cerebellum, which have been associated with erythrocytosis, were not found. The only associated disease was biopsy proven focal glomerulosclerosis. Renal vein thrombosis was excluded by renal venography and arteriography. This case illustrates the rarely reported association of the nephrotic syndrome and erythrocytosis. Other nephrogenic causes of erythrocytosis are mentioned, including renal cysts, tumors, renal artery stenosis and transplantation. The role of the kidney in erythropoietin production and possible mechanisms of nephrogenic erythrocytosis are discussed.

Original languageEnglish (US)
Title of host publicationJohns Hopkins Medical Journal
Pages192-195
Number of pages4
Volume145
Edition5
Publication statusPublished - 1979

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Myers, D. I., Ciuffo, A. A., & Cooke, C. R. (1979). Focal glomerulosclerosis and erythrocytosis. In Johns Hopkins Medical Journal (5 ed., Vol. 145, pp. 192-195)