TY - JOUR
T1 - FMRI functional connectivity applied to adolescent neurodevelopment
AU - Ernst, Monique
AU - Torrisi, Salvatore
AU - Balderston, Nicholas
AU - Grillon, Christian
AU - Hale, Elizabeth A.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - The exponential rise in the number of functional brain connectivity studies, particularly those examining intrinsic functional connectivity (iFC) at rest, and the promises of this work for unraveling the ontogeny of functional neural systems motivate this review. Shortly before this explosion in functional connectivity research, developmental neuroscientists had proposed theories based on neural systems models to explain behavioral changes, particularly in adolescence. The current review presents recent advances in imaging in brain connectivity research, which provides a unique tool for the study of neural systems. Understanding the potential of neuroimaging for refining neurodevelopmental models of brain function requires a description of various functional connectivity approaches. In this review, we describe task-based and resting-state functional magnetic resonance imaging (fMRI) analytic strategies, but we focus on iFC findings from resting-state data to describe general developmental trajectories of brain network organization. Finally, we use the example of drug addiction to frame a discussion of psychopathology that emerges in adolescence.
AB - The exponential rise in the number of functional brain connectivity studies, particularly those examining intrinsic functional connectivity (iFC) at rest, and the promises of this work for unraveling the ontogeny of functional neural systems motivate this review. Shortly before this explosion in functional connectivity research, developmental neuroscientists had proposed theories based on neural systems models to explain behavioral changes, particularly in adolescence. The current review presents recent advances in imaging in brain connectivity research, which provides a unique tool for the study of neural systems. Understanding the potential of neuroimaging for refining neurodevelopmental models of brain function requires a description of various functional connectivity approaches. In this review, we describe task-based and resting-state functional magnetic resonance imaging (fMRI) analytic strategies, but we focus on iFC findings from resting-state data to describe general developmental trajectories of brain network organization. Finally, we use the example of drug addiction to frame a discussion of psychopathology that emerges in adolescence.
KW - Development
KW - FMRI
KW - Intrinsic functional connectivity
KW - Networks
KW - Resting state
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U2 - 10.1146/annurev-clinpsy-032814-112753
DO - 10.1146/annurev-clinpsy-032814-112753
M3 - Article
C2 - 25581237
AN - SCOPUS:84964285132
SN - 1548-5943
VL - 11
SP - 361
EP - 377
JO - Annual Review of Clinical Psychology
JF - Annual Review of Clinical Psychology
ER -