FMRI evidence for multisensory recruitment associated with rapid eye movements during sleep

Charles Chong Hwa Hong, James C. Harris, Godfrey D. Pearlson, Jin Suh Kim, Vince D. Calhoun, James H. Fallon, Xavier Golay, Joseph S. Gillen, Daniel J. Simmonds, Peter C.M. Van Zijl, David S. Zee, James J. Pekar

Research output: Contribution to journalArticle

Abstract

We studied the neural correlates of rapid eye movement during sleep (REM) by timing REMs from video recording and using rapid event-related functional MRI. Consistent with the hypothesis that REMs share the brain systems and mechanisms with waking eye movements and are visually-targeted saccades, we found REM-locked activation in the primary visual cortex, thalamic reticular nucleus (TRN), 'visual claustrum', retrosplenial cortex (RSC, only on the right hemisphere), fusiform gyrus, anterior cingulate cortex, and the oculomotor circuit that controls awake saccadic eye movements (and subserves awake visuospatial attention). Unexpectedly, robust activation also occurred in non-visual sensory cortices, motor cortex, language areas, and the ascending reticular activating system, including basal forebrain, the major source of cholinergic input to the entire cortex. REM-associated activation of these areas, especially non-visual primary sensory cortices, TRN and claustrum, parallels findings from waking studies on the interactions between multiple sensory data, and their 'binding' into a unified percept, suggesting that these mechanisms are also shared in waking and dreaming and that the sharing goes beyond the expected visual scanning mechanisms. Surprisingly, REMs were associated with a decrease in signal in specific periventricular subregions, matching the distribution of the serotonergic supraependymal plexus.

Original languageEnglish (US)
Pages (from-to)1705-1722
Number of pages18
JournalHuman Brain Mapping
Volume30
Issue number5
DOIs
StatePublished - May 1 2009

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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