Abstract
fMRI has unique potential in the study of psychiatric patients, particularly in characterizing individual variations and changes over time. We have performed four studies of patients with schizophrenia, using three different fMRI acquisition protocols: (1) 3-D echo-shifted FLASH, a multishot volumetric approach; (2) 3-D PRESTO, a hybid of multishot and echo-planar imaging (EPI) methods that also acquires true volumetric data; and (3) a whole-brain isotropic, multislice EPI technique. Patients were studied during sensorimotor activation and during a novel 'N back' working memory paradigm. In general, patients show normal sensorimotor activation responses, although motor cortical activation tends to be less completely lateralized. Prefrontal activation during working memory tends to be reduced in patients with schizophrenia even when performance is normal. A major potential confound in studying this patient population with fMRI is the effect of motion. We propose several methodological standards to address this problem, including comparisons of motion corrections parameters, voxel variances, and the use of an 'internal activation standard'.
| Original language | English (US) |
|---|---|
| Journal | NeuroImage |
| Volume | 4 |
| Issue number | 3 SUPPL. 2 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neurology
- Cognitive Neuroscience
Cite this
fMRI applications in schizophrenia research. / Weinberger, Daniel; Mattay, Venkata; Callicott, Joseph; Kotrla, Kathryn; Santha, Attanagoda; Van Gelderen, Peter; Duyn, Jeff; Moonen, Chrit; Frank, Joseph.
In: NeuroImage, Vol. 4, No. 3 SUPPL. 2, 1996.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - fMRI applications in schizophrenia research
AU - Weinberger, Daniel
AU - Mattay, Venkata
AU - Callicott, Joseph
AU - Kotrla, Kathryn
AU - Santha, Attanagoda
AU - Van Gelderen, Peter
AU - Duyn, Jeff
AU - Moonen, Chrit
AU - Frank, Joseph
PY - 1996
Y1 - 1996
N2 - fMRI has unique potential in the study of psychiatric patients, particularly in characterizing individual variations and changes over time. We have performed four studies of patients with schizophrenia, using three different fMRI acquisition protocols: (1) 3-D echo-shifted FLASH, a multishot volumetric approach; (2) 3-D PRESTO, a hybid of multishot and echo-planar imaging (EPI) methods that also acquires true volumetric data; and (3) a whole-brain isotropic, multislice EPI technique. Patients were studied during sensorimotor activation and during a novel 'N back' working memory paradigm. In general, patients show normal sensorimotor activation responses, although motor cortical activation tends to be less completely lateralized. Prefrontal activation during working memory tends to be reduced in patients with schizophrenia even when performance is normal. A major potential confound in studying this patient population with fMRI is the effect of motion. We propose several methodological standards to address this problem, including comparisons of motion corrections parameters, voxel variances, and the use of an 'internal activation standard'.
AB - fMRI has unique potential in the study of psychiatric patients, particularly in characterizing individual variations and changes over time. We have performed four studies of patients with schizophrenia, using three different fMRI acquisition protocols: (1) 3-D echo-shifted FLASH, a multishot volumetric approach; (2) 3-D PRESTO, a hybid of multishot and echo-planar imaging (EPI) methods that also acquires true volumetric data; and (3) a whole-brain isotropic, multislice EPI technique. Patients were studied during sensorimotor activation and during a novel 'N back' working memory paradigm. In general, patients show normal sensorimotor activation responses, although motor cortical activation tends to be less completely lateralized. Prefrontal activation during working memory tends to be reduced in patients with schizophrenia even when performance is normal. A major potential confound in studying this patient population with fMRI is the effect of motion. We propose several methodological standards to address this problem, including comparisons of motion corrections parameters, voxel variances, and the use of an 'internal activation standard'.
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U2 - 10.1006/nimg.1996.0062
DO - 10.1006/nimg.1996.0062
M3 - Article
VL - 4
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 3 SUPPL. 2
ER -