fMRI applications in schizophrenia research

Daniel Weinberger, Venkata Mattay, Joseph Callicott, Kathryn Kotrla, Attanagoda Santha, Peter Van Gelderen, Jeff Duyn, Chrit Moonen, Joseph Frank

Research output: Contribution to journalArticle

Abstract

fMRI has unique potential in the study of psychiatric patients, particularly in characterizing individual variations and changes over time. We have performed four studies of patients with schizophrenia, using three different fMRI acquisition protocols: (1) 3-D echo-shifted FLASH, a multishot volumetric approach; (2) 3-D PRESTO, a hybid of multishot and echo-planar imaging (EPI) methods that also acquires true volumetric data; and (3) a whole-brain isotropic, multislice EPI technique. Patients were studied during sensorimotor activation and during a novel 'N back' working memory paradigm. In general, patients show normal sensorimotor activation responses, although motor cortical activation tends to be less completely lateralized. Prefrontal activation during working memory tends to be reduced in patients with schizophrenia even when performance is normal. A major potential confound in studying this patient population with fMRI is the effect of motion. We propose several methodological standards to address this problem, including comparisons of motion corrections parameters, voxel variances, and the use of an 'internal activation standard'.

Original languageEnglish (US)
JournalNeuroImage
Volume4
Issue number3 SUPPL. 2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Schizophrenia
Magnetic Resonance Imaging
Research
Echo-Planar Imaging
Short-Term Memory
Psychiatry
Brain
Population

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Weinberger, D., Mattay, V., Callicott, J., Kotrla, K., Santha, A., Van Gelderen, P., ... Frank, J. (1996). fMRI applications in schizophrenia research. NeuroImage, 4(3 SUPPL. 2). https://doi.org/10.1006/nimg.1996.0062

fMRI applications in schizophrenia research. / Weinberger, Daniel; Mattay, Venkata; Callicott, Joseph; Kotrla, Kathryn; Santha, Attanagoda; Van Gelderen, Peter; Duyn, Jeff; Moonen, Chrit; Frank, Joseph.

In: NeuroImage, Vol. 4, No. 3 SUPPL. 2, 1996.

Research output: Contribution to journalArticle

Weinberger, D, Mattay, V, Callicott, J, Kotrla, K, Santha, A, Van Gelderen, P, Duyn, J, Moonen, C & Frank, J 1996, 'fMRI applications in schizophrenia research', NeuroImage, vol. 4, no. 3 SUPPL. 2. https://doi.org/10.1006/nimg.1996.0062
Weinberger D, Mattay V, Callicott J, Kotrla K, Santha A, Van Gelderen P et al. fMRI applications in schizophrenia research. NeuroImage. 1996;4(3 SUPPL. 2). https://doi.org/10.1006/nimg.1996.0062
Weinberger, Daniel ; Mattay, Venkata ; Callicott, Joseph ; Kotrla, Kathryn ; Santha, Attanagoda ; Van Gelderen, Peter ; Duyn, Jeff ; Moonen, Chrit ; Frank, Joseph. / fMRI applications in schizophrenia research. In: NeuroImage. 1996 ; Vol. 4, No. 3 SUPPL. 2.
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