FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation

Sven G. Hyberts, Dominique P. Frueh, Haribabu Arthanari, Gerhard Wagner

Research output: Contribution to journalArticle

Abstract

Non-uniform sampling (NUS) enables recording of multidimensional NMR data at resolutions matching the resolving power of modern instruments without using excessive measuring time. However, in order to obtain satisfying results, efficient reconstruction methods are needed. Here we describe an optimized version of the Forward Maximum entropy (FM) reconstruction method, which can reconstruct up to three indirect dimensions. For complex datasets, such as NOESY spectra, the performance of the procedure is enhanced by a distillation procedure that reduces artifacts stemming from intense peaks.

Original languageEnglish (US)
Pages (from-to)283-294
Number of pages12
JournalJournal of Biomolecular NMR
Volume45
Issue number3
DOIs
StatePublished - Aug 26 2009
Externally publishedYes

Keywords

  • Data processing
  • Non-uniform sampling
  • Nuclear magnetic resonance
  • Protein structure
  • Sparse sampling

ASJC Scopus subject areas

  • Biochemistry
  • Spectroscopy

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