Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

Medicine & Life Sciences

• Fluvastatin 86%
• Glycosylation 61%
• Leukemia 48%
• Cell Survival 45%
• Protein-Tyrosine Kinases 40%
• Hydroxymethylglutaryl-CoA Reductase Inhibitors 29%
• Acute Myeloid Leukemia 28%
• lestaurtinib 27%
• Inhibitory Concentration 50 27%
• Sorafenib 18%
• Interleukin-3 17%
• United States Food and Drug Administration 14%
• Fluorescence Microscopy 14%
• Cell Death 11%
• Ligands 10%
• Phosphorylation 10%
• Mutation 8%
• Growth 7%
• Pharmaceutical Preparations 6%

Chemical Compounds

• Tyrosine Kinase Inhibitor 62%
• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 43%
• Resistance 37%
• Sorafenib 23%
• Growth Inhibition 17%
• Cell Death 15%
• Mutation 12%
• Surface 9%
• Drug 7%
• Reduction 6%
• Ligand 6%